Electrophysiologic and antiarrhythmic actions of nadolol: Acute ischemia in the presence of previous myocardial infarction
dc.contributor.author | Patterson, Eugene | en_US |
dc.contributor.author | Lucchesi, Benedict Robert | en_US |
dc.date.accessioned | 2006-04-07T20:09:40Z | |
dc.date.available | 2006-04-07T20:09:40Z | |
dc.date.issued | 1988-11 | en_US |
dc.identifier.citation | Patterson, Eugene, Lucchesi, Benedict R. (1988/11)."Electrophysiologic and antiarrhythmic actions of nadolol: Acute ischemia in the presence of previous myocardial infarction." American Heart Journal 116(5, Part 1): 1223-1232. <http://hdl.handle.net/2027.42/27090> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6W9H-4BT89KK-26/2/6221f1904ad04ab6d4930150c6eb630a | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27090 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3189140&dopt=citation | en_US |
dc.description.abstract | The actions of the [beta]-adrenergic receptor antagonist, d,l-nadolol, were examined in anesthetized dogs subjected to circumflex coronary artery ligation in the presence of previous anterior myocardial infarction. With circumflex ligation, control dogs (N = 18) developed premature ventricular boats and ventricular tachycardia, followed by ventricular fibrillation (N = 16, 89%). Immediate arrhythmias (2 to 5 minutes) were accompanied by activation delays and continuous diastolic electrical activity in acutely ischemic epicardial tissue. Delayed arrhythmias (6 to 12 minutes) were accompanied by delayed activation and continuous diastolic electrical activity in acutely ischemic mid-myocardium. Nadolol (8 mg/kg, intravenously) (N = 10) reduced ventricular arrhythmias during both phases of arrhythmia development and increased survival (70%, p = 0.001 vs control). Nadolol failed to alter activation in acutely ischemic epicardium, but prevented beat-to-beat changes in epicardial and mid-myocardial activation. Atrial pacing of nadolol-treated animals at heart rates comparable with those of the control group reversed the beneficial effects of nadolol on the development of ventricular arrhythmias and ventricular fibrillation (70%; p = 0.07 vs nadolol; p = 0.21 vs control, respectively). The beneficial effects of nadolol could not be attributed to reduced epicardial delays, but were associated with the suppression of beat-to-beat conduction abnormalities that preceded ventricular fibrillation. | en_US |
dc.format.extent | 1189548 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Electrophysiologic and antiarrhythmic actions of nadolol: Acute ischemia in the presence of previous myocardial infarction | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Mich., USA | en_US |
dc.identifier.pmid | 3189140 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27090/1/0000081.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0002-8703(88)90444-9 | en_US |
dc.identifier.source | American Heart Journal | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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