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Transforming growth factor beta stimulates phosphoinositol metabolism and translocation of protein kinase C in cultured astrocytes
dc.contributor.authorRobertson, Patricia L.en_US
dc.contributor.authorMarkovac, Jasnaen_US
dc.contributor.authorDatta, Subhash C.en_US
dc.contributor.authorGoldstein, Gary W.en_US
dc.date.accessioned2006-04-07T20:09:48Z
dc.date.available2006-04-07T20:09:48Z
dc.date.issued1988-10-31en_US
dc.identifier.citationRobertson, Patricia L., Markovac, Jasna, Datta, Subhash C., Goldstein, Gary W. (1988/10/31)."Transforming growth factor beta stimulates phosphoinositol metabolism and translocation of protein kinase C in cultured astrocytes." Neuroscience Letters 93(1): 107-113. <http://hdl.handle.net/2027.42/27092>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T0G-485H66M-JN/2/dc1309585d24a9d6f3da40bcf73c0403en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/27092
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3211365&dopt=citationen_US
dc.description.abstractTransforming growth factor beta (TGF-[beta]) is a regulatory peptide found in many normal and neoplastic tissues, including brain, with a diverse range of cellular effects. The transmembrane biochemical signals by which TGF-[beta] exerts these effects and the second messenger systems that may amplify them are unknown. We investigated the effects of TGF-[beta] upon membrane phosphoinositol metabolism and protein kinase C activity in cultured astrocytes. We found that exposure of astrocyte enriched cultures to TGF-[beta] resulted in the stimulation of phosphoinositol lipid turnover to inositol phosphates and in the apparent redistribution of protein kinase C from cytosol to membrane.en_US
dc.format.extent408453 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleTransforming growth factor beta stimulates phosphoinositol metabolism and translocation of protein kinase C in cultured astrocytesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelPsychologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelSocial Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pediatrics, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.identifier.pmid3211365en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/27092/1/0000083.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0304-3940(88)90021-3en_US
dc.identifier.sourceNeuroscience Lettersen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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