Effect of afterload alterations on the functional border zone measured with two-dimensional echocardiography during acute coronary occlusion
dc.contributor.author | Kavanaugh, Kevin M. | en_US |
dc.contributor.author | Brenner, Holly M. | en_US |
dc.contributor.author | Gallagher, Kim P. | en_US |
dc.contributor.author | Buda, Andrew J. | en_US |
dc.date.accessioned | 2006-04-07T20:11:30Z | |
dc.date.available | 2006-04-07T20:11:30Z | |
dc.date.issued | 1988-10 | en_US |
dc.identifier.citation | Kavanaugh, Kevin M., Brenner, Holly M., Gallagher, Kim P., Buda, Andrew J. (1988/10)."Effect of afterload alterations on the functional border zone measured with two-dimensional echocardiography during acute coronary occlusion." American Heart Journal 116(4): 942-953. <http://hdl.handle.net/2027.42/27132> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6W9H-4BTHDT8-B/2/1052f43d2fbac30b6439a1828b4713aa | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27132 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3177194&dopt=citation | en_US |
dc.description.abstract | In the setting of acute myocardial infarction, pharmacologic intervention resulting in afterload changes are common but the effect of these changes on regional left ventricular function, and specifically the functional border zone, has not been fully investigated. Accordingly, we studied the effects of afterload manipulation on circumferential flow-function relationships and the functional border zone in 16 open-chest, anesthetized dogs. During left circumflex coronary artery occlusion, eight animals were infused with phenylephrine to increase afterload; eight others received nitroprusside for afterload reduction. Following coronary artery occlusion, subendocardial blood flow and wall thickening decreased in the ischemic zone (p p = ns). Similarly, when blood pressure was increased by 47%, the extent of the functional border zone did not change (32 +/- 10 degrees vs 37 +/- 10 degrees). Therefore circumferential flow-function relations and the spatial extent of the functional border zone are not altered by changing afterload during acute left circumflex coronary artery occlusion in this model. | en_US |
dc.format.extent | 1335948 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Effect of afterload alterations on the functional border zone measured with two-dimensional echocardiography during acute coronary occlusion | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Cardiology Division, Department of Internal Medicine, Ann Arbor, Mich., USA; Department of Physiology, University of Michigan Medical School, Ann Arbor, Mich., USA; Department of Surgery, University of Michigan Medical School, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationum | Cardiology Division, Department of Internal Medicine, Ann Arbor, Mich., USA; Department of Physiology, University of Michigan Medical School, Ann Arbor, Mich., USA; Department of Surgery, University of Michigan Medical School, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationum | Cardiology Division, Department of Internal Medicine, Ann Arbor, Mich., USA; Department of Physiology, University of Michigan Medical School, Ann Arbor, Mich., USA; Department of Surgery, University of Michigan Medical School, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationum | Cardiology Division, Department of Internal Medicine, Ann Arbor, Mich., USA; Department of Physiology, University of Michigan Medical School, Ann Arbor, Mich., USA; Department of Surgery, University of Michigan Medical School, Ann Arbor, Mich., USA | en_US |
dc.identifier.pmid | 3177194 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27132/1/0000125.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0002-8703(88)90144-5 | en_US |
dc.identifier.source | American Heart Journal | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.