Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxofylline
dc.contributor.author | Strieter, Robert M. | en_US |
dc.contributor.author | Remick, Daniel G. | en_US |
dc.contributor.author | Ward, Peter A. | en_US |
dc.contributor.author | Spengler, Robert N. | en_US |
dc.contributor.author | Lynch III, J. P. | en_US |
dc.contributor.author | Larrick, James W. | en_US |
dc.contributor.author | Kunkel, Steven L. | en_US |
dc.date.accessioned | 2006-04-07T20:11:38Z | |
dc.date.available | 2006-04-07T20:11:38Z | |
dc.date.issued | 1988-09-30 | en_US |
dc.identifier.citation | Strieter, R.M., Remick, D.G., Ward, P.A., Spengler, R.N., Lynch III, J.P., Larrick, J., Kunkel, S.L. (1988/09/30)."Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxofylline." Biochemical and Biophysical Research Communications 155(3): 1230-1236. <http://hdl.handle.net/2027.42/27135> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-4G3D5KD-KY/2/bd4a00a56a3f92b8a6b110c359a6c470 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27135 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2460096&dopt=citation | en_US |
dc.description.abstract | Tumor necrosis factor-alpha (TNF), a mononuclear phagocyte (MO)-derived peptide, is increasingly being recognized for its pleomorphic immunologic effects. A number of investigations have demonstrated that lipopolysaccharide (LPS) can induce TNF synthesis, yet mechanisms that regulate TNF expression at the cellular and molecular levels have not been fully elucidated. In this study, we present data demonstrating pentoxifylline, a methylxanthine, is efficacious in suppressing LPS-induced MO-derived TNF at the level of both TNF mRNA accumulation and TNF supernatant bioactivity. Pentoxifylline, at a dose of 1 x 10-5M, suppressed the production of both biologically active TNF and TNF mRNA expression by more than 50%. Furthermore, additional methylxanthines and dibutyryl cAMP have similar effects on TNF expression. These data support the mechanism for this suppressive effect is via the generation of intracellular cAMP. | en_US |
dc.format.extent | 532631 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxofylline | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Psoriasis Research Institute, Stanford, California, USA; Genelabs Inc., Redwood City, California, USA | en_US |
dc.identifier.pmid | 2460096 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27135/1/0000128.pdf | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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