Effects of epinephrine in patients with an accessory atrioventricular connection treated with quinidine
dc.contributor.author | Morady, Fred | en_US |
dc.contributor.author | Kou, William H. | en_US |
dc.contributor.author | Kadish, Alan H. | en_US |
dc.contributor.author | Toivonen, Lauri K. | en_US |
dc.contributor.author | Kushner, Jeffrey A. | en_US |
dc.contributor.author | Schmaltz, Stephen P. | en_US |
dc.date.accessioned | 2006-04-07T20:11:45Z | |
dc.date.available | 2006-04-07T20:11:45Z | |
dc.date.issued | 1988-09-15 | en_US |
dc.identifier.citation | Morady, Fred, Kou, William H., Kadish, Alan H., Toivonen, Lauri K., Kushner, Jeffrey A., Schmaltz, Stephen (1988/09/15)."Effects of epinephrine in patients with an accessory atrioventricular connection treated with quinidine." The American Journal of Cardiology 62(9): 580-584. <http://hdl.handle.net/2027.42/27138> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T10-4C709XH-1JP/2/e88b330fd72a3b25d6d88d2cf87370cf | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27138 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3414550&dopt=citation | en_US |
dc.description.abstract | The purpose of this study was to determine whether physiologic doses of epinephrine reverse the electrophysiologic effects of quinidine in patients with an accessory atrioventricular (AV) connection. Eighteen patients with an accessory AV connection who had inducible sustained orthodromic tachycardia underwent an electrophysiologic study in the baseline state and after at least 2 days of treatment with 1.4 to 1.9 g/day of quinidine gluconate. The effects of epinephrine were then determined. Epinephrine infusion rates of 25 and 50 ng/ kg/min were used in 9 patients each because these doses of epinephrine previously have been demonstrated to result in elevated plasma epinephrine concentrations in the range that occurs during a variety of stresses in humans. Quinidine prolonged refractoriness in the atrium and accessory AV connection and slowed conduction through the accessory AV connection. These effects were partially or completely reversed by epinephrine. Among 8 patients in whom quinidine resulted in orthodromic tachycardia becoming noninducible or nonsustained, sustained tachycardia became inducible again in 5 patients after infusion of epinephrine. After quinidine, atrial fibrillation was either non-inducible or nonsustained in 8 patients; however, sustained atrial fibrillation could be induced in 4 of these patients after infusion of epinephrine. The results of this study demonstrate that the therapeutic effect of quinidine in patients who have an accessory AV connection are often reversed by physiologic increases in circulating epinephrine. | en_US |
dc.format.extent | 583409 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Effects of epinephrine in patients with an accessory atrioventricular connection treated with quinidine | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | The Division of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | The Division of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | The Division of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | The Division of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | The Division of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | The Division of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.identifier.pmid | 3414550 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27138/1/0000131.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0002-9149(88)90659-5 | en_US |
dc.identifier.source | The American Journal of Cardiology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.