Susceptibility to sensitization. I. Sex differences in the enduring effects of chronic -amphetamine treatment on locomotion, stereotyped behavior and brain monoamines
dc.contributor.author | Camp, Dianne M. | en_US |
dc.contributor.author | Robinson, Terry E. | en_US |
dc.date.accessioned | 2006-04-07T20:11:57Z | |
dc.date.available | 2006-04-07T20:11:57Z | |
dc.date.issued | 1988-09-01 | en_US |
dc.identifier.citation | Camp, Dianne M., Robinson, Terry E. (1988/09/01)."Susceptibility to sensitization. I. Sex differences in the enduring effects of chronic -amphetamine treatment on locomotion, stereotyped behavior and brain monoamines." Behavioural Brain Research 30(1): 55-68. <http://hdl.handle.net/2027.42/27142> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYP-484F33T-5S/2/bf35217446958b81c44ba5f357b83357 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27142 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2458741&dopt=citation | en_US |
dc.description.abstract | There are sex differences in a number of behaviors elicited by amphetamine (AMPH). The purpose of the present experiment was to determine if there are also sex differences in the sensitization of the locomotor activity and stereotypy produced by repeated intermittent AMPH treatment, and whether this is accompanied by sex differences in dopamine (DA) metabolism. It was found that female rats showed greater and more rapid sensitization of locomotor activity and stereotyped behavior than males. In addition, prior exposure to AMPH was associated with an elevation in resting striatal dihydroxyphenylacetic acid (DOPAC) to DA ratios in female, but not male rats, suggesting a sex difference in one neurochemical correlate of sensitization. As a group, males were more variable and heterogeneous in their response to repeated AMPH treatment, because they were divisible into two neurochemically distinct subgroups on the basis of their change in behavior and females were not. This heterogeneity may make it more difficult to identify neurochemical correlates of sensitization in males. It is suggested that there is a sex difference in the responsiveness of brain DA systems to repetitive activation, and this contributes to individual variation in the susceptibility to sensitization. | en_US |
dc.format.extent | 1258613 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Susceptibility to sensitization. I. Sex differences in the enduring effects of chronic -amphetamine treatment on locomotion, stereotyped behavior and brain monoamines | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychology, The University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Psychology, The University of Michigan, Ann Arbor, MI 48109, U.S.A.; Neuroscience Program, The University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 2458741 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27142/1/0000136.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0166-4328(88)90008-3 | en_US |
dc.identifier.source | Behavioural Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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