Mutagenicity of aromatic glycidyl ethers with Salmonella
dc.contributor.author | Rosman, L. B. | en_US |
dc.contributor.author | Chakraborty, Pulak K. | en_US |
dc.contributor.author | Messerly, E. A. | en_US |
dc.contributor.author | Sinsheimer, Joseph E. | en_US |
dc.date.accessioned | 2006-04-07T20:12:10Z | |
dc.date.available | 2006-04-07T20:12:10Z | |
dc.date.issued | 1988-09 | en_US |
dc.identifier.citation | Rosman, L. B., Chakraborty, P. K., Messerly, E. A., Sinsheimer, J. E. (1988/09)."Mutagenicity of aromatic glycidyl ethers with Salmonella." Mutation Research/Genetic Toxicology 206(1): 115-125. <http://hdl.handle.net/2027.42/27147> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B73FB-478BPVY-J/2/6bb89340ca281b4f69c336e777b82577 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27147 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3045534&dopt=citation | en_US |
dc.description.abstract | 6 aromatic glycidyl ethers containing naphthyl, biphenyl or benzylphenyl substituents were synthesized. These epoxides together with the commercially available compounds 2-biphenylyl glycidyl ether were examined for dose--mutagenicity relationships using the plate incorporation Ames test with Salmonella typhimurium strains TA100 and TA1535. Structure--mutagenicity relationships were further examined for these compounds and 3 phenyl glycidyl ethers by concurrent testing at a single dose with strain TA100. Meaningful correlations could not be established for the mutagenicity of these epoxides to their molecular volumes, partition values, nor to their reactivities with the model nucleophile, 4-(4-nitrobenzyl) pyridine. However, it was noted that increased conjugated aromatic unsaturation with its resulting planarity led to increased mutagenicity and that this effect decreased when it was further removed from the epoxide moiety. | en_US |
dc.format.extent | 688652 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Mutagenicity of aromatic glycidyl ethers with Salmonella | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, U.S.A. | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, U.S.A. | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, U.S.A. | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, U.S.A. | en_US |
dc.identifier.pmid | 3045534 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27147/1/0000141.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0165-1218(88)90147-4 | en_US |
dc.identifier.source | Mutation Research/Genetic Toxicology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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