Mutagenicity of aromatic glycidyl ethers with Salmonella

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dc.contributor.author Rosman, L. B. en_US
dc.contributor.author Chakraborty, Pulak K. en_US
dc.contributor.author Messerly, E. A. en_US
dc.contributor.author Sinsheimer, Joseph E. en_US
dc.date.accessioned 2006-04-07T20:12:10Z
dc.date.available 2006-04-07T20:12:10Z
dc.date.issued 1988-09 en_US
dc.identifier.citation Rosman, L. B., Chakraborty, P. K., Messerly, E. A., Sinsheimer, J. E. (1988/09)."Mutagenicity of aromatic glycidyl ethers with Salmonella." Mutation Research/Genetic Toxicology 206(1): 115-125. <http://hdl.handle.net/2027.42/27147> en_US
dc.identifier.uri http://www.sciencedirect.com/science/article/B73FB-478BPVY-J/2/6bb89340ca281b4f69c336e777b82577 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/27147
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3045534&dopt=citation en_US
dc.description.abstract 6 aromatic glycidyl ethers containing naphthyl, biphenyl or benzylphenyl substituents were synthesized. These epoxides together with the commercially available compounds 2-biphenylyl glycidyl ether were examined for dose--mutagenicity relationships using the plate incorporation Ames test with Salmonella typhimurium strains TA100 and TA1535. Structure--mutagenicity relationships were further examined for these compounds and 3 phenyl glycidyl ethers by concurrent testing at a single dose with strain TA100. Meaningful correlations could not be established for the mutagenicity of these epoxides to their molecular volumes, partition values, nor to their reactivities with the model nucleophile, 4-(4-nitrobenzyl) pyridine. However, it was noted that increased conjugated aromatic unsaturation with its resulting planarity led to increased mutagenicity and that this effect decreased when it was further removed from the epoxide moiety. en_US
dc.format.extent 688652 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language.iso en_US
dc.publisher Elsevier en_US
dc.title Mutagenicity of aromatic glycidyl ethers with Salmonella en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Molecular, Cellular and Developmental Biology en_US
dc.subject.hlbsecondlevel Genetics en_US
dc.subject.hlbsecondlevel Biological Chemistry en_US
dc.subject.hlbtoplevel Science en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, U.S.A. en_US
dc.contributor.affiliationum College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, U.S.A. en_US
dc.contributor.affiliationum College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, U.S.A. en_US
dc.contributor.affiliationum College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, U.S.A. en_US
dc.identifier.pmid 3045534 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/27147/1/0000141.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1016/0165-1218(88)90147-4 en_US
dc.identifier.source Mutation Research/Genetic Toxicology en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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