Retardation of calcification of bovine pericardium used in bioprosthetic heart valves by phosphocitrate and a synthetic analogue
dc.contributor.author | Tsao, Jack W. | en_US |
dc.contributor.author | Schoen, Frederick J. | en_US |
dc.contributor.author | Shankar, Ravi | en_US |
dc.contributor.author | Sallis, John D. | en_US |
dc.contributor.author | Levy, Robert J. | en_US |
dc.date.accessioned | 2006-04-07T20:12:50Z | |
dc.date.available | 2006-04-07T20:12:50Z | |
dc.date.issued | 1988-09 | en_US |
dc.identifier.citation | Tsao, Jack W., Schoen, Frederick J., Shankar, Ravi, Sallis, John D., Levy, Robert J. (1988/09)."Retardation of calcification of bovine pericardium used in bioprosthetic heart valves by phosphocitrate and a synthetic analogue." Biomaterials 9(5): 393-397. <http://hdl.handle.net/2027.42/27163> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TWB-48HRJFY-D4/2/fe9fcaf16b9dc04a25a93f76e18491ba | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27163 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3224124&dopt=citation | en_US |
dc.description.abstract | The purpose of this study was to determine if phosphocitrate (PC), a naturally occurring inhibitor of calcification, and its synthetic analogue, N-sulpho-2-amino tricarballylate (SAT), administered either by daily injection or local delivery via Alzet osmotic minipump, could inhibit calcification of glutaraldehyde-preserved bovine pericardium used in bioprosthetic heart valves, subcutaneously implanted in rats. Local drug delivery, but not systemic administration, was effective. PC, administered by Alzet minipump (12 mg.kg-1.day-1), inhibited calcification significantly (tissue calcium = 5 +/- 2 [mu]g/mg dry tissue, mean +/- SEM), compared with untreated or saline-treated controls (89 +/-9 and 49 +/- 9 [mu]g/mg, respectively). SAT, administered by the same route at both the same and a higher molar dosage, was less potent (tissue calcium = 26 +/- 9 [mu]g/mg and 17 +/- 5 [mu]g/mg, respectively). PC and SAT therapy were not associated with adverse effects. We conclude that locally administered PC and SAT can inhibit intrinsic calcification of bovine pericardium, with PC being more potent. | en_US |
dc.format.extent | 1006126 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Retardation of calcification of bovine pericardium used in bioprosthetic heart valves by phosphocitrate and a synthetic analogue | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Radiology | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbsecondlevel | Dentistry | en_US |
dc.subject.hlbsecondlevel | Biomedical Engineering | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pediatric Cardiology, Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Department of Pathology, Brigham and Women's Hospital, Department of Pathology, Harvard Medical School, Boston, MA, USA | en_US |
dc.contributor.affiliationother | Department of Pathology, Brigham and Women's Hospital, Department of Pathology, Harvard Medical School, Boston, MA, USA | en_US |
dc.contributor.affiliationother | Department of Biochemistry, University of Tasmania, Tasmania, Australia | en_US |
dc.contributor.affiliationother | Department of Biochemistry, University of Tasmania, Tasmania, Australia | en_US |
dc.identifier.pmid | 3224124 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27163/1/0000158.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0142-9612(88)90002-6 | en_US |
dc.identifier.source | Biomaterials | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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