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Neurotoxicity of is markedly enhanced in developing rat central nervous system
dc.contributor.authorMcDonald, John W.en_US
dc.contributor.authorSilverstein, Faye Sarahen_US
dc.contributor.authorJohnston, Michael V.en_US
dc.date.accessioned2006-04-07T20:13:19Z
dc.date.available2006-04-07T20:13:19Z
dc.date.issued1988-08-30en_US
dc.identifier.citationMcDonald, John W., Silverstein, Faye S., Johnston, Michael V. (1988/08/30)."Neurotoxicity of is markedly enhanced in developing rat central nervous system." Brain Research 459(1): 200-203. <http://hdl.handle.net/2027.42/27174>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6SYR-483SN0P-K0/2/1a4678c75e1c8aa7f96a7d6a414673d7en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/27174
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3048538&dopt=citationen_US
dc.description.abstractThe neurotoxic lesion produced by direct injection of 25 nmol of (NMDA) into the corpus striatum of 7-day-old rats was compared to the effects of injecting 75 nmol into the striatum or hippocampus of adults. The area of histopathology in the immature striatum was 21 x larger than the striatal lesions in adults. Damage from NMDA injected into the immature striatum also extended into the dorsal hippocampus and produced an area of destruction which was 16 x larger than observed after direct injection into the adult hippocampus. Several studies have implicated excessive receptor activation in the pathogenesis of hypopoxic-ischemic and hypoglycemic injury and our results suggest that this neurotoxic mechanism is extremely active in the immature brain.en_US
dc.format.extent413807 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleNeurotoxicity of is markedly enhanced in developing rat central nervous systemen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumNeuroscience Training Program, University of Michigan Medical School, Ann Arbor, MI, U.S.A.en_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan Medical School, Ann Arbor, MI, U.S.A.; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, U.S.A.en_US
dc.contributor.affiliationumNeuroscience Training Program, University of Michigan Medical School, Ann Arbor, MI, U.S.A.; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, U.S.A.; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, U.S.A.; Center for Human Growth and Development, Ann Arbor, MI, U.S.A.en_US
dc.identifier.pmid3048538en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/27174/1/0000171.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-8993(88)90306-Xen_US
dc.identifier.sourceBrain Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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