Cochlear blood flow increases after systemic hemodilution: Comparison of simultaneous laser doppler flowmetry and radioactive microsphere measurements
dc.contributor.author | Nuttall, Alfred L. | en_US |
dc.contributor.author | Hultcrantz, Elisabeth | en_US |
dc.contributor.author | Larsen, Hans-Christian | en_US |
dc.contributor.author | Angelborg, Clarence | en_US |
dc.date.accessioned | 2006-04-07T20:14:20Z | |
dc.date.available | 2006-04-07T20:14:20Z | |
dc.date.issued | 1988-08 | en_US |
dc.identifier.citation | Nuttall, Alfred L., Hultcrantz, Elisabeth, Larsen, Hans-Christian, Angelborg, Clarence (1988/08)."Cochlear blood flow increases after systemic hemodilution: Comparison of simultaneous laser doppler flowmetry and radioactive microsphere measurements." Hearing Research 34(3): 215-223. <http://hdl.handle.net/2027.42/27192> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T73-485GDRS-2P/2/9b4a623973307ff134eb48607c23a961 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27192 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2459097&dopt=citation | en_US |
dc.description.abstract | Guinea pig cochlear blood flow was measured before and after systemic normovolemic hemodilution with high molecular weight dextran. Absolute determinations of blood flow (in the cochlea, brain, kidney and lung) were accomplished by use of radioactive-labeled (85Sr or 141Ce) microspheres. Relative measurements of the cochlear blood flow changes were made simultaneously by the use of a laser Doppler flowmeter. The flowmeter probe was placed on the first cochlear turn. Hemodilution to an average systemic hematocrit of 20% increased cochlear blood flow by 250% as measured with microspheres. The laser Doppler instrument significantly underestimated the actual flow increase giving an indication of 148%. Furthermore, the data, when analyzed on an individual trial basis, showed a very poor correlation between the two methods. The theoretical basis for these findings in relation to the use of the laser Doppler instrument is discussed. | en_US |
dc.format.extent | 907683 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Cochlear blood flow increases after systemic hemodilution: Comparison of simultaneous laser doppler flowmetry and radioactive microsphere measurements | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, Department of Otolaryngology Head and Neck Surgery, Medical School, The University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Otorhinolaryngology, University Hospital, Uppsala, Sweden | en_US |
dc.contributor.affiliationother | Department of Otorhinolaryngology, University Hospital, Uppsala, Sweden | en_US |
dc.contributor.affiliationother | Department of Otorhinolaryngology, University Hospital, Uppsala, Sweden | en_US |
dc.identifier.pmid | 2459097 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27192/1/0000195.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0378-5955(88)90001-9 | en_US |
dc.identifier.source | Hearing Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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