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The effect of glycosidases on the survival of rat erythrocytes in circulation

dc.contributor.authorGutowski, Karol A.en_US
dc.contributor.authorLinseman, Daniel A.en_US
dc.contributor.authorAminoff, Daviden_US
dc.date.accessioned2006-04-07T20:15:21Z
dc.date.available2006-04-07T20:15:21Z
dc.date.issued1988-07-15en_US
dc.identifier.citationGutowski, Karol A., Linseman, Daniel A., Aminoff, David (1988/07/15)."The effect of glycosidases on the survival of rat erythrocytes in circulation." Carbohydrate Research 178(1): 307-313. <http://hdl.handle.net/2027.42/27216>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6TFF-42VMPXF-81/2/23352af1a3d257007e3a58976ff4b2c8en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/27216
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3191511&dopt=citationen_US
dc.description.abstractEnzymic removal of sialyl groups from mammalian erythrocytes resulted in their rapid sequestration from circulation subsequent to autologous transfusion. It has been demonstrated by many investigators that the terminal [beta]--galactosyl group, exposed on red blood cell by in vitro desialosylation, is recognized by an autoimmune anti-galactosyl IgG and/or by a lectin-like receptor on monocytes and macrophages. It is demonstrated herein that the disaccharide structure [beta]--Galp-(1--&gt;3)--GalpNAc (a) is masked in normal rat RBC, but exposed in asialo-RBC; (b) could be detected with fluorescently-labeled peanut agglutinin; (c) could be released from the asialo-RBC with an endo-N-acetyl-[alpha]--galactosaminidase; and (d) upon its removal by treatment with the endo-N-acetyl-[alpha]--galactosaminidase, enhances the survival of the asialo-RBC in circulation.en_US
dc.format.extent514933 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleThe effect of glycosidases on the survival of rat erythrocytes in circulationen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelMaterials Science and Engineeringen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumInstitute of Gerontology and Department of Biological Chemistry, The University of Michigan, Ann Arbor, Michigan 48109 U.S.A.en_US
dc.contributor.affiliationumInstitute of Gerontology and Department of Biological Chemistry, The University of Michigan, Ann Arbor, Michigan 48109 U.S.A.en_US
dc.contributor.affiliationumInstitute of Gerontology and Department of Biological Chemistry, The University of Michigan, Ann Arbor, Michigan 48109 U.S.A.en_US
dc.identifier.pmid3191511en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/27216/1/0000220.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0008-6215(88)80120-4en_US
dc.identifier.sourceCarbohydrate Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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