MSG effects on beta-endorphin and alpha-MSH in the hypothalamus and caudal medulla
dc.contributor.author | Alessi, Norman E. | en_US |
dc.contributor.author | Quinlan, Paul E. | en_US |
dc.contributor.author | Khachaturian, Henry | en_US |
dc.date.accessioned | 2006-04-07T20:17:14Z | |
dc.date.available | 2006-04-07T20:17:14Z | |
dc.date.issued | 1988 | en_US |
dc.identifier.citation | Alessi, Norman E., Quinlan, Paul, Khachaturian, Henry (1988)."MSG effects on beta-endorphin and alpha-MSH in the hypothalamus and caudal medulla." Peptides 9(4): 689-695. <http://hdl.handle.net/2027.42/27254> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0M-47SVC34-1C/2/10ac35483aac5fb1b97d946485e75094 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27254 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2852357&dopt=citation | en_US |
dc.description.abstract | Monosodium glutamate (MSG) was given to neonatal male rats to determine its effects on neurons containing beta-endorphin ([beta]-END) and alpha-melanocyte stimulating hormone ([alpha]-MSH) within the basal hypothalamus (arcuate nucleus) and caudal medulla [nucleus tractus solitarius (NTS)] and on the levels of [beta]-END and [alpha]-MSH within these areas. Immunocytochemical studies demonstrated a reduction in the number of cells within the medial hypothalamic area (arcuate nucleus) amon MSG-treated animals versus saline controls. MSG did not reduce the number of cell bodies within the caudal medulla (NTS). MSG significantly reduced [beta]-END and [alpha]-MSH immunoreactive levels in the basal hypothalamus as determined by radioimmunoassay. Whereas a significant reduction in the level of [beta]-END occurred in the ventral caudal medulla (VCM), none occurred in the dorsal caudal medulla (DCM). In contrast, levels of [alpha]-MSH increased significantly in the DCM among animals receiving MSG compared to control animals. This study documents the contribution of beta-endorphin containing neurons of the basal hypothalamus to areas of the caudal medulla. The effect of MSG on beta-endorphin and [alpha]-MSH neurons in these areas and their differential effects on levels in the caudal medulla areas raises questions about the sites of origin of these peptides. | en_US |
dc.format.extent | 669183 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | MSG effects on beta-endorphin and alpha-MSH in the hypothalamus and caudal medulla | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychiatry, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Psychiatry, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationother | Department of Anatomy and Neurobiology, University of Tennessee College of Medicine, Memphis, TN 38163, USA | en_US |
dc.identifier.pmid | 2852357 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27254/1/0000263.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0196-9781(88)90108-8 | en_US |
dc.identifier.source | Peptides | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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