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Differential scanning calorimetric studies on frozen cephalosporin solutions
dc.contributor.authorWilliams, N. Adeyinkaen_US
dc.contributor.authorPolli, G. P.en_US
dc.date.accessioned2006-04-07T20:17:54Z
dc.date.available2006-04-07T20:17:54Z
dc.date.issued1988-06en_US
dc.identifier.citationWilliams, N. Adeyinka, Polli, G. P. (1988/06)."Differential scanning calorimetric studies on frozen cephalosporin solutions." International Journal of Pharmaceutics 44(1-3): 205-212. <http://hdl.handle.net/2027.42/27271>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T7W-478BNXW-1X/2/3b814b8042ee2248938a2fd912ac316den_US
dc.identifier.urihttps://hdl.handle.net/2027.42/27271
dc.description.abstractThe difficulty of formulating cephalosporins as freeze-dried products lies in the freezing characteristics of their aqueous solutions. The thermal characteristics of aqueous solutions of several cephalosporins were examined by Differential Scanning Calorimetry (DSC) during freezing and warming cycles. It was found that the observed compounds do not crystallize from such solutions and do not form eutectic mixtures with water. Also, freezing did not produce any detectable metastable states of the solutes. Therefore, in the determination of parameters to be used in designing an optimum freeze-drying cycle for compounds such as these, DSC may be of limited use.en_US
dc.format.extent683679 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleDifferential scanning calorimetric studies on frozen cephalosporin solutionsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumCollege of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, U.S.A.en_US
dc.contributor.affiliationotherSmith Kline & French Laboratories, Research and Development Division, King of Prussia, PA 19406-0939, U.S.A.en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/27271/1/0000286.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0378-5173(88)90117-2en_US
dc.identifier.sourceInternational Journal of Pharmaceuticsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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