Increase in experimental infarct size with digoxin in a canine model of myocardial ischemia-reperfusion injury
dc.contributor.author | Lynch, Joseph J. | en_US |
dc.contributor.author | Simpson, Paul J. | en_US |
dc.contributor.author | Gallagher, Kim P. | en_US |
dc.contributor.author | McClanahan, Thomas B. | en_US |
dc.contributor.author | Lee, Karl A. | en_US |
dc.contributor.author | Lucchesi, Benedict Robert | en_US |
dc.date.accessioned | 2006-04-07T20:18:30Z | |
dc.date.available | 2006-04-07T20:18:30Z | |
dc.date.issued | 1988-06 | en_US |
dc.identifier.citation | Lynch, Joseph J., Simpson, Paul J., Gallagher, Kim P., McClanahan, Thomas B., Lee, Karl A., Lucchesi, Benedict R. (1988/06)."Increase in experimental infarct size with digoxin in a canine model of myocardial ischemia-reperfusion injury." American Heart Journal 115(6): 1171-1182. <http://hdl.handle.net/2027.42/27287> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6W9H-4BYSSVS-6G/2/0787529946f325f70d9603350f486c9b | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27287 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3376834&dopt=citation | en_US |
dc.description.abstract | In the present study, dogs were pretreated with intravenous digoxin, 0.0125 mg/kg/day, for 6 to 7 consecutive days to achieve clinically relevant serum concentrations; untreated animals were used as control subjects. After pretreatment, nine digoxin-pretreated dogs and nine control dogs were anesthetized and subjected to a 60-minute occlusion of the left circumflex coronary artery, followed by 6 hours of reperfusion. Anatomic myocardial infarct size, expressed as a percentage of the areas at risk of infarction and as a percentage of the total left ventricle were: 20.2 +/- 3.3% control vs 35.4 +/- 6.2% digoxin-pretreated (p p < 0.05), respectively (2.04 +/- 0.37 ng/ml serum digoxin). Regional myocardial blood flow in the nonischemic and ischemic zones tended to be lower in digoxin-pretreated than in control animals at baseline testing and were significantly reduced in the anterior subendocardial sites of digoxin-pretreated dogs during ischemia and reperfusion. These data suggest that an exacerbation or enhancement of myocardial ischemial-reperfusion injury may occur in the presence of clinically observable serum digoxin concentrations. | en_US |
dc.format.extent | 1594354 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Increase in experimental infarct size with digoxin in a canine model of myocardial ischemia-reperfusion injury | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Pharmacology, Physiology, and Surgery, and the Thoracic Surgery Research Laboratory, The University of Michigan Medical School, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationum | Departments of Pharmacology, Physiology, and Surgery, and the Thoracic Surgery Research Laboratory, The University of Michigan Medical School, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationum | Departments of Pharmacology, Physiology, and Surgery, and the Thoracic Surgery Research Laboratory, The University of Michigan Medical School, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationum | Departments of Pharmacology, Physiology, and Surgery, and the Thoracic Surgery Research Laboratory, The University of Michigan Medical School, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationum | Departments of Pharmacology, Physiology, and Surgery, and the Thoracic Surgery Research Laboratory, The University of Michigan Medical School, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationum | Departments of Pharmacology, Physiology, and Surgery, and the Thoracic Surgery Research Laboratory, The University of Michigan Medical School, Ann Arbor, Mich., USA | en_US |
dc.identifier.pmid | 3376834 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27287/1/0000306.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0002-8703(88)90004-X | en_US |
dc.identifier.source | American Heart Journal | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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