Reduction of the same calcium current component by A and C kinases: Differential pertussis toxin sensitivity
dc.contributor.author | Gross, Robert A. | en_US |
dc.contributor.author | Macdonald, Robert L. | en_US |
dc.date.accessioned | 2006-04-07T20:18:43Z | |
dc.date.available | 2006-04-07T20:18:43Z | |
dc.date.issued | 1988-05-16 | en_US |
dc.identifier.citation | Gross, Robert A., Macdonald, Robert L. (1988/05/16)."Reduction of the same calcium current component by A and C kinases: Differential pertussis toxin sensitivity." Neuroscience Letters 88(1): 50-56. <http://hdl.handle.net/2027.42/27293> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0G-485RMHY-YF/2/bf6f97b1d910c9c8350bbf961c945ee5 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27293 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2456492&dopt=citation | en_US |
dc.description.abstract | Voltage-clamp techniques were used to study the effect of forskolin, 8-Br-cyclic AMP, and phorbol 12,13-dibutyrate (PDBu) on the 3 voltage-dependent calcium current components of mouse dorsal root ganglion neurons in culture. Forskolin and 8-Br-cyclic AMP selectively reduced the transient high-threshold (N-type) calcium current component, an effect also produced by PDBu, a C kinase activator. Pretreatment of cultures with pertussis toxin prevented the reduction of calcium current by PDBu, but was without effect on the reductions produced by forskolin or 8-Br-cyclic AMP. These results support the contention that activation of both A and C kinases selectively affect calcium currents in vertebrate neurons by reducing the N-type calcium current component. While the activation of the C kinase required a G protein to exert its effect, the activation of A kinase did not. | en_US |
dc.format.extent | 376510 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Reduction of the same calcium current component by A and C kinases: Differential pertussis toxin sensitivity | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan Medical Center, Ann Arbor, MI 48104-1687, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan Medical Center, Ann Arbor, MI 48104-1687, U.S.A. | en_US |
dc.identifier.pmid | 2456492 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27293/1/0000312.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0304-3940(88)90314-X | en_US |
dc.identifier.source | Neuroscience Letters | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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