Heparin inhibits the growth of astrocytes in vitro
dc.contributor.author | Robertson, Patricia L. | en_US |
dc.contributor.author | Goldstein, Gary W. | en_US |
dc.date.accessioned | 2006-04-07T20:18:53Z | |
dc.date.available | 2006-04-07T20:18:53Z | |
dc.date.issued | 1988-05-03 | en_US |
dc.identifier.citation | Robertson, Patricia L., Goldstein, Gary W. (1988/05/03)."Heparin inhibits the growth of astrocytes in vitro." Brain Research 447(2): 341-345. <http://hdl.handle.net/2027.42/27296> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYR-484NG18-RD/2/164420cc787621fd73ebe02b0269d4aa | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27296 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3390702&dopt=citation | en_US |
dc.description.abstract | Heparin at a concentration of 100 [mu]g/ml, inhibits neonatal rat astrocyte proliferation by 45%, and [3H]thymidine incorporation into DNA by 55% when they are stimulated with 2% fetal bovine serum (FBS) in culture. Higher serum concentrations up to 10% FBS decreased this inhibition to 20% and 29% respectively. Inhibition of [3H]thymidine incorporation by heparin is dose-dependent with maximal inhibition at 100 [mu]g/ml, but 39% inhibition is still seen at 1 [mu]g/ml on stimulation by 5% FBS. Heparin or heparin-like molecules in the extracellular matrix of brain capillary walls may be important in the regulation of astrocyte growth in vivo. | en_US |
dc.format.extent | 511475 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Heparin inhibits the growth of astrocytes in vitro | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pediatrics and Neurology, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Pediatrics and Neurology, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 3390702 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27296/1/0000316.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-8993(88)91137-7 | en_US |
dc.identifier.source | Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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