Cervical carcinoma antigen: Distribution in neoplastic lesions of the uterine cervix and comparison to other tumor markers
dc.contributor.author | Flint, Andrew | en_US |
dc.contributor.author | McCoy, J. Philip Jr. | en_US |
dc.contributor.author | Schade, William J. | en_US |
dc.contributor.author | Hofheinz, David A. | en_US |
dc.contributor.author | Haines, Harold G. | en_US |
dc.date.accessioned | 2006-04-07T20:19:03Z | |
dc.date.available | 2006-04-07T20:19:03Z | |
dc.date.issued | 1988-05 | en_US |
dc.identifier.citation | Flint, Andrew, McCoy, Jr., J. Philip, Schade, William J., Hofheinz, David A., Haines, Harold G. (1988/05)."Cervical carcinoma antigen: Distribution in neoplastic lesions of the uterine cervix and comparison to other tumor markers." Gynecologic Oncology 30(1): 63-70. <http://hdl.handle.net/2027.42/27300> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WG6-4C5GY1S-B6/2/0087b9e175dd191af95835701cb42371 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27300 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2452772&dopt=citation | en_US |
dc.description.abstract | Four antibodies (anti-CCA, anti-CEA, Ca-1, and anti-EMA) were used to study the distribution of antibody-binding sites in normal endocervical mucosa, metaplastic squamous epithelium, squamous epithelium exhibiting varying grades of intraepithelial neoplasia, and invasive squamous cell carcinoma. Anti-CCA, a novel monoclonal antibody raised against an extract of squamous cell carcinoma of the cervix, recognizes dysplastic, neoplastic, and metaplastic cervical epithelial cells. While anti-CCA and Ca-1 rarely stained normal glandular epithelium, 31.4 and 45.7% of the samples stained positively for CEA and EMA, respectively. There did not appear to be significant differences between anti-CCA and the other antibodies in the frequency with which neoplastic conditions were stained. Based upon these observations, it appears that none of the antibodies tested can be regarded as a specific tumor marker. | en_US |
dc.format.extent | 1017908 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Cervical carcinoma antigen: Distribution in neoplastic lesions of the uterine cervix and comparison to other tumor markers | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Otolaryngology | en_US |
dc.subject.hlbsecondlevel | Ophthalmology | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbsecondlevel | Obstetrics and Gynecology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109-0054, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109-0054, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109-0054, U.S.A. | en_US |
dc.contributor.affiliationother | Coulter Corporation, Hialeah, Florida, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Obstetrics and Gynecology, University of Miami School of Medicine, Miami, Florida, U.S.A. | en_US |
dc.identifier.pmid | 2452772 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27300/1/0000321.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0090-8258(88)90047-9 | en_US |
dc.identifier.source | Gynecologic Oncology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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