Normalization of liver glucosylceramide levels in the "Gaucher" mouse by phosphatidylserine injection
dc.contributor.author | Datta, Subhash C. | en_US |
dc.contributor.author | Radin, Norman S. | en_US |
dc.date.accessioned | 2006-04-07T20:20:21Z | |
dc.date.available | 2006-04-07T20:20:21Z | |
dc.date.issued | 1988-04-15 | en_US |
dc.identifier.citation | Datta, Subhash C., Radin, Norman S. (1988/04/15)."Normalization of liver glucosylceramide levels in the "Gaucher" mouse by phosphatidylserine injection." Biochemical and Biophysical Research Communications 152(1): 155-160. <http://hdl.handle.net/2027.42/27332> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-4FW08RV-NN/2/479390231f2a3630628bc896df159f84 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27332 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3358758&dopt=citation | en_US |
dc.description.abstract | A model of the human genetic disorder, Gaucher disease, can be rapidly generated in mice by the injection of emulsified glucosylceramide and an inhibitor of the lipid's hydrolase, conduritol B epoxide. The liver grows rapidly as it absorbs the load of lipid but the effect disappears as new glucosidase is formed and the load is hydrolyzed. This normalization process is accelerated by treatment with phosphatidylserine, which is a known stimulator of the enzyme. It is possible that injecting the phospholipid into Gaucher patients would have a therapeutic effect since it might help them utilize their residual glucosidase to destroy stored glycolipid. | en_US |
dc.format.extent | 410616 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Normalization of liver glucosylceramide levels in the "Gaucher" mouse by phosphatidylserine injection | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 3358758 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27332/1/0000357.pdf | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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