Spectrin and calmodulin in spreading mouse blastomeres
dc.contributor.author | Sobel, J. Sabina | en_US |
dc.contributor.author | Goldstein, Elaine G. | en_US |
dc.contributor.author | Venuti, Judith M. | en_US |
dc.contributor.author | Welsh, Michael J. | en_US |
dc.date.accessioned | 2006-04-07T20:22:02Z | |
dc.date.available | 2006-04-07T20:22:02Z | |
dc.date.issued | 1988-03 | en_US |
dc.identifier.citation | Sobel, J. Sabina, Goldstein, Elaine G., Venuti, Judith M., Welsh, Michael J. (1988/03)."Spectrin and calmodulin in spreading mouse blastomeres." Developmental Biology 126(1): 47-56. <http://hdl.handle.net/2027.42/27372> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WDG-4DTS5MH-2B/2/095d64461831d48b77030cff938f4c77 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27372 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3277881&dopt=citation | en_US |
dc.description.abstract | The role of spectrin and its association with calmodulin in spreading mouse blastomeres was investigated. Embryonic spectrin binds 125I-calmodulin in a calcium-dependent fashion in the blot overlay technique. Double-labeling experiments show coordinate redistribution of spectrin and calmodulin in blastomeres preparing to undergo active spreading movement. At this stage cortical spectrin staining is lost from the region of cell-substrate contact and spectrin and calmodulin become concentrated in two structures closely associated with the contacted region: a group of spherical bodies located on the cytoplasmic side of the cortical layer and a subcortical ring that marks the perimeter of the contacted region. The localization pattern of spectrin and calmodulin is also coordinated with that of actin and myosin. The results suggest that spectrin plays a role in the spreading of blastomeres and that this function may involve linkage of spectrin, calmodulin, and the cortical contractile apparatus. | en_US |
dc.format.extent | 8449619 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Spectrin and calmodulin in spreading mouse blastomeres | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Anatomy and Cell Biology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationother | Department of Anatomical Sciences, State University of New York at Buffalo, Buffalo, New York 14214, USA | en_US |
dc.contributor.affiliationother | Department of Anatomical Sciences, State University of New York at Buffalo, Buffalo, New York 14214, USA | en_US |
dc.contributor.affiliationother | Department of Zoology, University of Texas, Austin, Texas 78712, USA | en_US |
dc.identifier.pmid | 3277881 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27372/1/0000399.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0012-1606(88)90237-0 | en_US |
dc.identifier.source | Developmental Biology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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