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Translocation t(3;8)(p14.2;q24.1) in renal cell carcinoma affects expression of the common fragile site at 3p14(FRA3B) in lymphocytes

dc.contributor.authorGlover, Thomas W.en_US
dc.contributor.authorCoyle-Morris, Jane F.en_US
dc.contributor.authorLi, Frederick P.en_US
dc.contributor.authorBrown, Robert S.en_US
dc.contributor.authorBerger, Carol S.en_US
dc.contributor.authorGemmill, Robert M.en_US
dc.contributor.authorHecht, Fredericken_US
dc.date.accessioned2006-04-07T20:22:10Z
dc.date.available2006-04-07T20:22:10Z
dc.date.issued1988-03en_US
dc.identifier.citationGlover, Thomas W., Coyle-Morris, Jane F., Li, Frederick P., Brown, Robert S., Berger, Carol S., Gemmill, Robert M., Hecht, Frederick (1988/03)."Translocation t(3;8)(p14.2;q24.1) in renal cell carcinoma affects expression of the common fragile site at 3p14(FRA3B) in lymphocytes." Cancer Genetics and Cytogenetics 31(1): 69-73. <http://hdl.handle.net/2027.42/27374>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T53-47RJPJJ-5D/2/c8c56f33f5b1190ad2c4d2c424abaaecen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/27374
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3125959&dopt=citationen_US
dc.description.abstractThe common fragile site at 3p14(FRA3B) is cytogenetically close to the positions of translocation and deletion breakpoints frequently observed in renal cell carcinoma (RCC) and small cell carcinoma of the lung. Possible involvement of this fragile site in the familial RCC t(3;8)(p14.2;q24.1) was investigated. Expression of FRA3B, induced by treatment of lymphocytes with aphidicolin, is altered by the translocation. These results suggest that the fragile site is very close to, if not coincident with, the translocation breakpoint.en_US
dc.format.extent259040 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleTranslocation t(3;8)(p14.2;q24.1) in renal cell carcinoma affects expression of the common fragile site at 3p14(FRA3B) in lymphocytesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelOncology and Hematologyen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, USA; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.en_US
dc.contributor.affiliationotherGenetics Center of Southwest Biomedical Research Institute, Scottsdale, AZ, USA; Cancer Center of Southwest Biomedical Research Institute, Scottsdale, AZ, USA.en_US
dc.contributor.affiliationotherSidney Farber Cancer Institute, Boston, MA, USAen_US
dc.contributor.affiliationotherBeth Israel Hospital, Boston, MA, USAen_US
dc.contributor.affiliationotherGenetics Center of Southwest Biomedical Research Institute, Scottsdale, AZ, USA; Cancer Center of Southwest Biomedical Research Institute, Scottsdale, AZ, USA.en_US
dc.contributor.affiliationotherGenetics Center of Southwest Biomedical Research Institute, Scottsdale, AZ, USA; Cancer Center of Southwest Biomedical Research Institute, Scottsdale, AZ, USA.en_US
dc.contributor.affiliationotherGenetics Center of Southwest Biomedical Research Institute, Scottsdale, AZ, USA; Cancer Center of Southwest Biomedical Research Institute, Scottsdale, AZ, USA.en_US
dc.identifier.pmid3125959en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/27374/1/0000401.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0165-4608(88)90013-1en_US
dc.identifier.sourceCancer Genetics and Cytogeneticsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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