Benefits and risks of menopausal estrogen and/or progestin hormone use,
dc.contributor.author | Ernster, Virginia L. | en_US |
dc.contributor.author | Bush, Trudy L. | en_US |
dc.contributor.author | Huggins, George R. | en_US |
dc.contributor.author | Hulka, Barbara S. | en_US |
dc.contributor.author | Kelsey, Jennifer L. | en_US |
dc.contributor.author | Schottenfeld, David | en_US |
dc.date.accessioned | 2006-04-07T20:22:36Z | |
dc.date.available | 2006-04-07T20:22:36Z | |
dc.date.issued | 1988-03 | en_US |
dc.identifier.citation | Ernster, Virginia L., Bush, Trudy L., Huggins, George R., Hulka, Barbara S., Kelsey, Jennifer L., Schottenfeld, David (1988/03)."Benefits and risks of menopausal estrogen and/or progestin hormone use,." Preventive Medicine 17(2): 201-223. <http://hdl.handle.net/2027.42/27382> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WPG-4BNJ9DB-29R/2/873f5761816b3eb5e128007c709c3c4c | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27382 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2843846&dopt=citation | en_US |
dc.description.abstract | Current evidence is reviewed here on risks and benefits of estrogen and progestin use by peri- and postmenopausal women in relation to the following conditions: endometrial cancer, breast cancer, osteoporosis, and coronary artery disease (CAD). On balance, estrogen therapy appears to be beneficial for menopausal women, as it probably reduces the risks of CAD and osteoporosis, two of the major causes of mortality and morbidity. Although unopposed estrogen therapy increases the risk of endometrial cancer, that cancer is relatively rare and is not fatal in the vast majority of cases associated with estrogen use. Definitive conclusions about the relation of menopausal estrogens to breast cancer cannot be drawn due to inconsistent evidence to date. Although evidence from randomized controlled trials is lacking, biochemical and clinical evidence suggest that progestin supplementation is associated with a reduction in endometrial cancer risk in women taking menopausal estrogens. Progestin supplementation also may augment the beneficial effects of estrogens in providing protection against osteoporosis, although this effect is not yet well established. There is little direct evidence bearing on the relation of menopausal progestins to breast cancer. Although studies of CAD per se are lacking at present, progestins probably unfavorably alter lipoprotein profiles, thereby increasing a user's risk of CAD. Given the relatively high incidence and mortality of CAD in postmenopausal women, any negative effects on CAD risk could potentially counterbalance beneficial effects on other causes. We conclude that estrogen replacement therapy is of potential benefit to postmenopausal women, but that the question of progestin supplementation requires further study, particularly for CAD risk. | en_US |
dc.format.extent | 1797591 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Benefits and risks of menopausal estrogen and/or progestin hormone use, | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationother | Department of Epidemiology and International Health, School of Medicine, University of California, San Francisco, California 94143, USA | en_US |
dc.contributor.affiliationother | Department of Epidemiology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA | en_US |
dc.contributor.affiliationother | Department of Obstetrics and Gynecology, Francis Scott Key Medical Center, 4940 Eastern Avenue, Baltimore, Maryland 21224, USA | en_US |
dc.contributor.affiliationother | Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27514, USA | en_US |
dc.contributor.affiliationother | Division of Epidemiology, School of Public Health, Columbia University, New York, New York 10032, USA | en_US |
dc.identifier.pmid | 2843846 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27382/1/0000412.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0091-7435(88)90064-3 | en_US |
dc.identifier.source | Preventive Medicine | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.