Failure of -carnitine to protect mice against ammonia toxicity
dc.contributor.author | Deshmukh, Devendra R. | en_US |
dc.contributor.author | Rusk, Cynthia D. | en_US |
dc.date.accessioned | 2006-04-07T20:24:24Z | |
dc.date.available | 2006-04-07T20:24:24Z | |
dc.date.issued | 1988-02 | en_US |
dc.identifier.citation | Deshmukh, Devendra R., Rusk, Cynthia D. (1988/02)."Failure of -carnitine to protect mice against ammonia toxicity." Biochemical Medicine and Metabolic Biology 39(1): 126-130. <http://hdl.handle.net/2027.42/27412> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBN-4C4NVPG-CF/2/d1c0d2e2d68d7cc2e49d5b1ec56ac1ab | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27412 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3355710&dopt=citation | en_US |
dc.description.abstract | Recent reports indicate that intraperitoneal administration of -carnitine protects mice from ammonia toxicity. We found that mice injected with -carnitine and subsequently challenged with ammonium acetate succumb as readily as mice injected with saline and the ammonium acetate. Mice pretreated with -carnitine exhibited higher levels of liver ammonia than the saline-pretreated control mice. The ammonia and urea levels in serum and brains were similar in two groups. Our findings are in contrast to those reported previously and therefore warrants further investigation before -carnitine can be considered as a drug to alleviate hyperammonemia in humans. | en_US |
dc.format.extent | 335161 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Failure of -carnitine to protect mice against ammonia toxicity | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pediatrics and Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Pediatrics and Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 3355710 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27412/1/0000446.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0885-4505(88)90068-0 | en_US |
dc.identifier.source | Biochemical Medicine and Metabolic Biology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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