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The effect of systemic cocaine on spinal nociceptive reflex activity in the rat
dc.contributor.authorPertovaara, Anttien_US
dc.contributor.authorBelczynski, Carl R.en_US
dc.contributor.authorMorrow, Thomas J.en_US
dc.contributor.authorCasey, Kenneth L.en_US
dc.date.accessioned2006-04-07T20:25:30Z
dc.date.available2006-04-07T20:25:30Z
dc.date.issued1988-01-12en_US
dc.identifier.citationPertovaara, Antti, Belczynski, Carl R., Morrow, Thomas J., Casey, Kenneth L. (1988/01/12)."The effect of systemic cocaine on spinal nociceptive reflex activity in the rat." Brain Research 438(1-2): 286-290. <http://hdl.handle.net/2027.42/27430>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6SYR-47XN6JY-4W/2/fef487adca1e27ccf31777a88b8c5dceen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/27430
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3345433&dopt=citationen_US
dc.description.abstractIn the anesthetized rat, cocaine (25 mg/kg i.p.), enhanced the frequency potentiation of nociceptively evoked polysynaptic discharges but did not affect the polysynaptic reflex discharge to single nociceptive stimuli or the habituation of this reflex to repetitive pinch stimuli. The non-nociceptive, short-latency reflex discharge was suppressed for 10-15 min after cocaine administration. The neurogenic extravasation response to antidromic cutaneous C-fiber stimulation was unaffected by cocaine. These findings suggest that systemic cocaine, in doses analgesic for the rat, does not suppress spinal nociceptive reflexes.en_US
dc.format.extent506296 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleThe effect of systemic cocaine on spinal nociceptive reflex activity in the raten_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartments of Physiology and Neurology, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Neurophysiology Research Laboratories, Veterans Administration Medical Center, Ann Arbor, MI 48105, U.S.A.en_US
dc.contributor.affiliationumNeurophysiology Research Laboratories, Veterans Administration Medical Center, Ann Arbor, MI 48105, U.S.A.; Departments of Physiology and Neurology, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumNeurophysiology Research Laboratories, Veterans Administration Medical Center, Ann Arbor, MI 48105, U.S.A.; Departments of Physiology and Neurology, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumNeurophysiology Research Laboratories, Veterans Administration Medical Center, Ann Arbor, MI 48105, U.S.A.; Departments of Physiology and Neurology, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.identifier.pmid3345433en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/27430/1/0000468.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-8993(88)91348-0en_US
dc.identifier.sourceBrain Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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