Increased immunoglobulin response to [gamma]-interferon by lymphocytes from patients with systemic lupus erythematosus
dc.contributor.author | Golbus, Joseph | en_US |
dc.contributor.author | Salata, Michael | en_US |
dc.contributor.author | Greenwood, Jay | en_US |
dc.contributor.author | Hudson, Jerry L. | en_US |
dc.contributor.author | Richardson, Bruce C. | en_US |
dc.date.accessioned | 2006-04-07T20:28:43Z | |
dc.date.available | 2006-04-07T20:28:43Z | |
dc.date.issued | 1988-01 | en_US |
dc.identifier.citation | Golbus, Joseph, Salata, Michael, Greenwood, Jay, Hudson, Jerry, Richardson, Bruce C. (1988/01)."Increased immunoglobulin response to [gamma]-interferon by lymphocytes from patients with systemic lupus erythematosus." Clinical Immunology and Immunopathology 46(1): 129-140. <http://hdl.handle.net/2027.42/27486> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WCK-4BJW1PM-KM/2/0331ae16698e418dc08133035af168a8 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27486 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3121224&dopt=citation | en_US |
dc.description.abstract | The factors responsible for abnormal B-cell activation in systemic lupus erythematosus (SLE) are incompletely understood. This study tested the hypothesis that the abnormal B-cell activation observed in human SLE may be due to an augmented response to a helper signal. We demonstrated that non-T cells from 10 of 19 SLE patients increased IgG production in response to interferon-[gamma] (IFN-[gamma]) by a mean factor of 20.9 +/- 3.9 over resting levels, while controls stimulated a mean factor of 3.0 +/- 0.5 (P < 0.005). We found no relationship of IFN-[gamma] responsiveness to disease activity. Serotyping for HLA A, B, C, and D loci suggested that the hyperresponsiveness may be genetically linked to HLA-Cw7. We conclude that IFN-[gamma] may contribute to the development and perpetuation of SLE in a subset of patients with SLE. | en_US |
dc.format.extent | 861537 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Increased immunoglobulin response to [gamma]-interferon by lymphocytes from patients with systemic lupus erythematosus | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan, 48109, USA; Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, 48109, USA. | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan, 48109, USA; Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, 48109, USA. | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan, 48109, USA; Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, 48109, USA. | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan, 48109, USA; Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, 48109, USA. | en_US |
dc.contributor.affiliationum | Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, 48109, USA; Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan, 48109, USA | en_US |
dc.identifier.pmid | 3121224 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27486/1/0000529.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0090-1229(88)90013-X | en_US |
dc.identifier.source | Clinical Immunology and Immunopathology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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