Inhibition by coenzyme Q of ethanol- and carbon tetrachloride-stimulated lipid peroxidation in vivo and catalyzed by microsomal and mitochondrial systems
dc.contributor.author | Beyer, Robert E. | en_US |
dc.date.accessioned | 2006-04-07T20:30:46Z | |
dc.date.available | 2006-04-07T20:30:46Z | |
dc.date.issued | 1988 | en_US |
dc.identifier.citation | Beyer, Robert E. (1988)."Inhibition by coenzyme Q of ethanol- and carbon tetrachloride-stimulated lipid peroxidation in vivo and catalyzed by microsomal and mitochondrial systems." Free Radical Biology and Medicine 5(5-6): 297-303. <http://hdl.handle.net/2027.42/27527> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T38-47P8D1W-60/2/c3905f92bcceb348f4009785cc8483fc | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27527 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3256528&dopt=citation | en_US |
dc.description.abstract | The ability of coenzyme Q to inhibit lipid peroxidation in intact animals as well as in mitochondrial, submitochondrial, and microsomal systems has been tested. Rats fed coenzyme Q prior to being treated with carbon tetrachloride or while being treated with ethanol excrete less thiobarbituric acid-reacting material in the urine than such rats not fed coenzyme Q. Liver homogenates, mitochondria, and microsomes isolated from rats treated with carbon tetrachloride and ethanol catalyze lipid peroxidation at rates which exceed those from animals also fed coenzyme Q. The rate of lipid peroxidation catalyzed by submitochondrial particles isolated from hearts of young, old, and endurance trained elderly rats was inversely proportional to the coenzyme Q content of the submitochondrial preparation in assays in which succinate was employed to reduce the endogenous coenzyme Q. Reduced, but not oxidized, coenzyme Q inhibited lipid peroxidation catalyzed by rat liver microsomal preparations. These results provide additional evidence in support of an antioxidant role for coenzyme Q. | en_US |
dc.format.extent | 662332 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Inhibition by coenzyme Q of ethanol- and carbon tetrachloride-stimulated lipid peroxidation in vivo and catalyzed by microsomal and mitochondrial systems | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biology, The University of Michigan, Ann Arbor, MI 48109-1048, U.S.A. | en_US |
dc.identifier.pmid | 3256528 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27527/1/0000571.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0891-5849(88)90100-1 | en_US |
dc.identifier.source | Free Radical Biology and Medicine | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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