The Safety After Fifty Evaluation trial: Evaluation of the safety and efficacy of antihypertensive therapy with metoprolol in patients 50 to 75 years of age: Study design
dc.contributor.author | Rich, Michael W. | en_US |
dc.contributor.author | LaPalio, Lawrence | en_US |
dc.contributor.author | Schork, Anthony | en_US |
dc.contributor.author | SAFE Coordinators | en_US |
dc.date.accessioned | 2006-04-07T20:30:53Z | |
dc.date.available | 2006-04-07T20:30:53Z | |
dc.date.issued | 1988-07 | en_US |
dc.identifier.citation | Rich, Michael W., LaPalio, Lawrence, Schork, Anthony, SAFE Coordinators, (1988/07)."The Safety After Fifty Evaluation trial: Evaluation of the safety and efficacy of antihypertensive therapy with metoprolol in patients 50 to 75 years of age: Study design." American Heart Journal 116(1, Part 2): 301-304. <http://hdl.handle.net/2027.42/27529> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6W9H-4CN4MJB-19V/2/7494f2e5c43c2d0a3299dd6fd27943e1 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27529 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3293397&dopt=citation | en_US |
dc.description.abstract | Hypertension increases in prevalence with advancing age and is a major risk factor for the development of cardiovascular disease in elderly patients. However, the presence of coexisting illness, altered drug metabolism, enhanced susceptibility to drug side effects, and physiologic changes such as reduced plasma volume and lower plasma renin levels make truatment of hypertension in elderly patients more difficult. Nonetheless, several studies have now demonstrated the beneficial effects of antihypertensive drug therapy in older parlents. The Safety After Fifty Evaluation trial was designed to determine the short-term efficacy and tolerabillty of once-daily therapy with the cardioselective [beta]-blocker metoprolol anone or in combination with hydrochlorothiazide in the treatment of mild hypertension in patients 50 to 75 years of age. A total of 24,816 patients were enrolled in the trial by 2821 practicing physicians from across the United States. This article describes the detalls of the Safety After Fiffy Evaluation study design. Results of the trial will be reported separately. | en_US |
dc.format.extent | 479141 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The Safety After Fifty Evaluation trial: Evaluation of the safety and efficacy of antihypertensive therapy with metoprolol in patients 50 to 75 years of age: Study design | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Geriatric Cardiology Section, Jewish Hospital at Washington University, St. Louis, Mo., USA; Department of Geriatrics, Loyola-Strick School of Medicine, Chicago, Ill., USA; Department of Biostatistics, University of Michigan School of Medicine and School of Public Health, Ann Aroor, Mich., USA | en_US |
dc.contributor.affiliationum | Department of Geriatrics, Loyola-Strick School of Medicine, Chicago, Ill., USA; Department of Biostatistics, University of Michigan School of Medicine and School of Public Health, Ann Arbor, Mich., USA; Geriatric Cardiology Section, Jewish Hospital at Washington University, St. Louis, Mo., USA. | en_US |
dc.contributor.affiliationum | Department of Geriatrics, Loyola-Strick School of Medicine, Chicago, Ill., USA; Department of Biostatistics, University of Michigan School of Medicine and School of Public Health, Ann Arbor, Mich., USA; Geriatric Cardiology Section, Jewish Hospital at Washington University, St. Louis, Mo., USA. | en_US |
dc.contributor.affiliationum | Department of Geriatrics, Loyola-Strick School of Medicine, Chicago, Ill., USA; Department of Biostatistics, University of Michigan School of Medicine and School of Public Health, Ann Arbor, Mich., USA; Geriatric Cardiology Section, Jewish Hospital at Washington University, St. Louis, Mo., USA. | en_US |
dc.identifier.pmid | 3293397 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27529/1/0000573.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0002-8703(88)90104-4 | en_US |
dc.identifier.source | American Heart Journal | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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