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Glutamate transmission and toxicity in alzheimer's disease

dc.contributor.authorGreenamyre, J. Timothyen_US
dc.contributor.authorMaragos, William F.en_US
dc.contributor.authorAlbin, Roger L.en_US
dc.contributor.authorPenney, John B.en_US
dc.contributor.authorYoung, Anne B.en_US
dc.date.accessioned2006-04-07T20:32:23Z
dc.date.available2006-04-07T20:32:23Z
dc.date.issued1988en_US
dc.identifier.citationGreenamyre, J. Timothy, Maragos, William F., Albin, Roger L., Penney, John B., Young, Anne B. (1988)."Glutamate transmission and toxicity in alzheimer's disease." Progress in Neuro-Psychopharmacology and Biological Psychiatry 12(4): 421-430. <http://hdl.handle.net/2027.42/27563>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6TBR-474XM22-5/2/12e6c1f3bdc61517367b313c19362e15en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/27563
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2900537&dopt=citationen_US
dc.description.abstract1. 1. Despite intensive research, the cause of Alzheimer's disease is unknown.2. 2. Glutamate is the major excitatory transmitter of the cerebral cortex and hippocampus and it appears to have an important role in learning and memory. In addition to its transmitter function, glutamate is a neurotoxin which has been implicated in the pathogenesis of a variety of neurodegenerative disorders.3. 3. Glutamate toxicity may play a role in the pathogenesis of Alzheimer's disease.4. 4. Disruption of glutamatergic neurotransmission may account, in part, for the learning and memory deficits of Alzheimer's disease.5. 5. Labeling of the glutamate receptor complex may allow in vivo diagnosis by positron emission tomography.6. 6. Glutamate receptor ligands may provide a means of therapeutic intervention in Alzhefmer's disease.en_US
dc.format.extent553521 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleGlutamate transmission and toxicity in alzheimer's diseaseen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Neurology and Neuroscience Program, University of Michigan Medical Center, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Neurology and Neuroscience Program, University of Michigan Medical Center, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Neurology and Neuroscience Program, University of Michigan Medical Center, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Neurology and Neuroscience Program, University of Michigan Medical Center, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Neurology and Neuroscience Program, University of Michigan Medical Center, Ann Arbor, MI, USAen_US
dc.identifier.pmid2900537en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/27563/1/0000607.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0278-5846(88)90102-9en_US
dc.identifier.sourceProgress in Neuro-Psychopharmacology and Biological Psychiatryen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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