A captive solvent method for rapid N-[11C]methylation of secondary amides: Application to the benzodiazepine, 4'-chlorodiazepam (RO5-4864)
dc.contributor.author | Leonard Watkins, G. | en_US |
dc.contributor.author | Jewett, Douglas M. | en_US |
dc.contributor.author | Keith Mulholland, G. | en_US |
dc.contributor.author | Kilbourn, Michael R. | en_US |
dc.contributor.author | Toorongian, Steven A. | en_US |
dc.date.accessioned | 2006-04-07T20:32:28Z | |
dc.date.available | 2006-04-07T20:32:28Z | |
dc.date.issued | 1988 | en_US |
dc.identifier.citation | Leonard Watkins, G., Jewett, Douglas M., Keith Mulholland, G., Kilbourn, Michael R., Toorongian, Steven A. (1988)."A captive solvent method for rapid N-[11C]methylation of secondary amides: Application to the benzodiazepine, 4'-chlorodiazepam (RO5-4864)." International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes 39(5): 441-444. <http://hdl.handle.net/2027.42/27565> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6X3S-46Y3JPK-WK/2/0ddb25ae48c14e3c31f78f20591e240e | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27565 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2840421&dopt=citation | en_US |
dc.description.abstract | [11C]4'-Chlorodiazepam (RO5-4864), for PET studies of peripheral benzodiazepine receptors, was synthesized by alkylation of 1-desmethyl-4'-chlorodiazepam, in a small volume of acetone adsorbed on acrylic yarn, with [11C]methyl iodide in the injection loop of a liquid chromatograph. The reaction mixture was introduced directly onto a small, disposable alumina chromatographic column. Elution with pentane:ethanol gave a product of high chemical and radiochemical purity. A simple heating and cooling device for the injection loop is described. | en_US |
dc.format.extent | 392832 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | A captive solvent method for rapid N-[11C]methylation of secondary amides: Application to the benzodiazepine, 4'-chlorodiazepam (RO5-4864) | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Physics | en_US |
dc.subject.hlbsecondlevel | Nuclear Engineering and Radiological Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Cyclotron/PET Facility, Division of Nuclear Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0552, U.S.A. | en_US |
dc.contributor.affiliationum | Cyclotron/PET Facility, Division of Nuclear Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0552, U.S.A. | en_US |
dc.contributor.affiliationum | Cyclotron/PET Facility, Division of Nuclear Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0552, U.S.A. | en_US |
dc.contributor.affiliationum | Cyclotron/PET Facility, Division of Nuclear Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0552, U.S.A. | en_US |
dc.contributor.affiliationum | Cyclotron/PET Facility, Division of Nuclear Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0552, U.S.A. | en_US |
dc.identifier.pmid | 2840421 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27565/1/0000609.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0883-2889(88)90077-9 | en_US |
dc.identifier.source | International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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