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A captive solvent method for rapid N-[11C]methylation of secondary amides: Application to the benzodiazepine, 4'-chlorodiazepam (RO5-4864)
dc.contributor.authorLeonard Watkins, G.en_US
dc.contributor.authorJewett, Douglas M.en_US
dc.contributor.authorKeith Mulholland, G.en_US
dc.contributor.authorKilbourn, Michael R.en_US
dc.contributor.authorToorongian, Steven A.en_US
dc.date.accessioned2006-04-07T20:32:28Z
dc.date.available2006-04-07T20:32:28Z
dc.date.issued1988en_US
dc.identifier.citationLeonard Watkins, G., Jewett, Douglas M., Keith Mulholland, G., Kilbourn, Michael R., Toorongian, Steven A. (1988)."A captive solvent method for rapid N-[11C]methylation of secondary amides: Application to the benzodiazepine, 4'-chlorodiazepam (RO5-4864)." International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes 39(5): 441-444. <http://hdl.handle.net/2027.42/27565>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6X3S-46Y3JPK-WK/2/0ddb25ae48c14e3c31f78f20591e240een_US
dc.identifier.urihttps://hdl.handle.net/2027.42/27565
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2840421&dopt=citationen_US
dc.description.abstract[11C]4'-Chlorodiazepam (RO5-4864), for PET studies of peripheral benzodiazepine receptors, was synthesized by alkylation of 1-desmethyl-4'-chlorodiazepam, in a small volume of acetone adsorbed on acrylic yarn, with [11C]methyl iodide in the injection loop of a liquid chromatograph. The reaction mixture was introduced directly onto a small, disposable alumina chromatographic column. Elution with pentane:ethanol gave a product of high chemical and radiochemical purity. A simple heating and cooling device for the injection loop is described.en_US
dc.format.extent392832 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleA captive solvent method for rapid N-[11C]methylation of secondary amides: Application to the benzodiazepine, 4'-chlorodiazepam (RO5-4864)en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPhysicsen_US
dc.subject.hlbsecondlevelNuclear Engineering and Radiological Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumCyclotron/PET Facility, Division of Nuclear Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0552, U.S.A.en_US
dc.contributor.affiliationumCyclotron/PET Facility, Division of Nuclear Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0552, U.S.A.en_US
dc.contributor.affiliationumCyclotron/PET Facility, Division of Nuclear Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0552, U.S.A.en_US
dc.contributor.affiliationumCyclotron/PET Facility, Division of Nuclear Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0552, U.S.A.en_US
dc.contributor.affiliationumCyclotron/PET Facility, Division of Nuclear Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0552, U.S.A.en_US
dc.identifier.pmid2840421en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/27565/1/0000609.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0883-2889(88)90077-9en_US
dc.identifier.sourceInternational Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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