Life table tests of evolutionary theories of senescence

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dc.contributor.author Nesse, Randolph M. en_US
dc.date.accessioned 2006-04-07T20:32:30Z
dc.date.available 2006-04-07T20:32:30Z
dc.date.issued 1988 en_US
dc.identifier.citation Nesse, Randolph M. (1988)."Life table tests of evolutionary theories of senescence." Experimental Gerontology 23(6): 445-453. <http://hdl.handle.net/2027.42/27566> en_US
dc.identifier.uri http://www.sciencedirect.com/science/article/B6T6J-47S118X-4R/2/2f022f4d578181b04d86ac5785d47897 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/27566
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3250881&dopt=citation en_US
dc.description.abstract The phenomenon of senescence requires both evolutionary and proximate explanations. The most widely accepted evolutionary explanation for senescence is that it never gets exposed to natural selection because environmental hazards kill all individuals before the age at which senescence causes decreased fitness. If this explanation is sufficient, wild populations should not demonstrate senescence, and their mortality rates should therefore remain constant during adult life, except when environmental causes of mortality have recently decreased. The alternative explanation for the persistence of the genes that cause senescence is that they have been selected for because they have pleiotropic effects that are beneficial early in life when the force of selection is strongest. Where this is the case, mortality rates should increase with age in wild populations. A method is described for using life table data to calculate an estimate of the intensity of selection acting on senescence in wild populations. This method is applied to a variety of life tables. The results suggest that pleiotropic genes may be important causes of senescence in some populations, but not in others. This has implications for research on the proximate mechanisms of senescence. en_US
dc.format.extent 616191 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language.iso en_US
dc.publisher Elsevier en_US
dc.title Life table tests of evolutionary theories of senescence en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Molecular, Cellular and Developmental Biology en_US
dc.subject.hlbsecondlevel Geriatrics en_US
dc.subject.hlbtoplevel Science en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Department of Psychiatry, C 440 Med-Inn Building, University of Michigan Medical School, Ann Arbor, Michigan 48109-0840, USA en_US
dc.identifier.pmid 3250881 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/27566/1/0000610.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1016/0531-5565(88)90056-3 en_US
dc.identifier.source Experimental Gerontology en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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