Life table tests of evolutionary theories of senescence
dc.contributor.author | Nesse, Randolph M. | en_US |
dc.date.accessioned | 2006-04-07T20:32:30Z | |
dc.date.available | 2006-04-07T20:32:30Z | |
dc.date.issued | 1988 | en_US |
dc.identifier.citation | Nesse, Randolph M. (1988)."Life table tests of evolutionary theories of senescence." Experimental Gerontology 23(6): 445-453. <http://hdl.handle.net/2027.42/27566> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T6J-47S118X-4R/2/2f022f4d578181b04d86ac5785d47897 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27566 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3250881&dopt=citation | en_US |
dc.description.abstract | The phenomenon of senescence requires both evolutionary and proximate explanations. The most widely accepted evolutionary explanation for senescence is that it never gets exposed to natural selection because environmental hazards kill all individuals before the age at which senescence causes decreased fitness. If this explanation is sufficient, wild populations should not demonstrate senescence, and their mortality rates should therefore remain constant during adult life, except when environmental causes of mortality have recently decreased. The alternative explanation for the persistence of the genes that cause senescence is that they have been selected for because they have pleiotropic effects that are beneficial early in life when the force of selection is strongest. Where this is the case, mortality rates should increase with age in wild populations. A method is described for using life table data to calculate an estimate of the intensity of selection acting on senescence in wild populations. This method is applied to a variety of life tables. The results suggest that pleiotropic genes may be important causes of senescence in some populations, but not in others. This has implications for research on the proximate mechanisms of senescence. | en_US |
dc.format.extent | 616191 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Life table tests of evolutionary theories of senescence | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Geriatrics | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychiatry, C 440 Med-Inn Building, University of Michigan Medical School, Ann Arbor, Michigan 48109-0840, USA | en_US |
dc.identifier.pmid | 3250881 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27566/1/0000610.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0531-5565(88)90056-3 | en_US |
dc.identifier.source | Experimental Gerontology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.