The effect of different mechanisms of myocardial ischemia on left ventricular function
dc.contributor.author | Carlson, Robert E. | en_US |
dc.contributor.author | Kavanaugh, Kevin M. | en_US |
dc.contributor.author | Buda, Andrew J. | en_US |
dc.date.accessioned | 2006-04-07T20:32:50Z | |
dc.date.available | 2006-04-07T20:32:50Z | |
dc.date.issued | 1988-08 | en_US |
dc.identifier.citation | Carlson, Robert E., Kavanaugh, Kevin M., Buda, Andrew J. (1988/08)."The effect of different mechanisms of myocardial ischemia on left ventricular function." American Heart Journal 116(2, Part 1): 536-545. <http://hdl.handle.net/2027.42/27575> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6W9H-4BSVHWK-122/2/8fa9f556e613a96b57fdfd1dd4fe08a7 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27575 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3400571&dopt=citation | en_US |
dc.description.abstract | Myocardial ischemia may be produced by limitation of blood flow as in abrupt coronary occlusion, termed supply-type ischemia, or by increasing myocardial oxygen demand in the setting of restricted flow, termed demand-type ischemia. To examine the comparative extent and severity of the dysfunction related to both forms of ischemia, we studied anesthetized, open-chest dogs by means of two-dimensional echocardiography and tracer microspheres. Supply-type ischemia was produced by total occlusion of the LCx (n = 7); demand-type ischemia was induced by infusion of dobutamine after creation of a critical LCx stenosis (n = 6). At the time of the production of ischemia, the group with demand-type ischemia had significant increases in both heart rate (p p p p p p < 0.05). Thus these data suggest that supply-type ischemia produced by coronary occlusion results in a greater extent and degree of left ventricular functional abnormality than pharmacologically induced demand-type ischemia. | en_US |
dc.format.extent | 1104195 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The effect of different mechanisms of myocardial ischemia on left ventricular function | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Cardiology Division, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationum | Cardiology Division, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationum | Cardiology Division, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Mich., USA | en_US |
dc.identifier.pmid | 3400571 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27575/1/0000619.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0002-8703(88)90629-1 | en_US |
dc.identifier.source | American Heart Journal | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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