Herpes simplex virus type 1 ribonucleotide reductase null mutants induce lesions in guinea pigs
dc.contributor.author | Turk, Steven R. | en_US |
dc.contributor.author | Kik, Natalie A. | en_US |
dc.contributor.author | Birch, Gary M. | en_US |
dc.contributor.author | Chiego, Jr. , Daniel J. | en_US |
dc.contributor.author | Shipman, Jr. , C. | en_US |
dc.date.accessioned | 2006-04-07T20:38:38Z | |
dc.date.available | 2006-04-07T20:38:38Z | |
dc.date.issued | 1989-12 | en_US |
dc.identifier.citation | Turk, Steven R., Kik, Natalie A., Birch, Gary M., Chiego, Jr., Daniel J., Shipman, Jr., C. (1989/12)."Herpes simplex virus type 1 ribonucleotide reductase null mutants induce lesions in guinea pigs." Virology 173(2): 733-735. <http://hdl.handle.net/2027.42/27674> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WXR-4BKB9B9-2W/2/fa8619b9396575b8201250a06e7f9fa7 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27674 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2556851&dopt=citation | en_US |
dc.description.abstract | Two herpes simplex virus type 1 ribonucleotide reductase null mutants, hrR3 and ICP6[Delta], produced cutaneous lesions in guinea pigs as severe as those of wild-type strains. The lesions induced by hrR3 resulted from in vivo replication of the mutant virus, suggesting that this virus-encoded enzyme is nonessential for virus replication in guinea pigs. | en_US |
dc.format.extent | 3587915 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Herpes simplex virus type 1 ribonucleotide reductase null mutants induce lesions in guinea pigs | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biologic and Materials Sciences, School of Dentistry The University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Biologic and Materials Sciences, School of Dentistry The University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Biologic and Materials Sciences, School of Dentistry The University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Biologic and Materials Sciences, School of Dentistry The University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Biologic and Materials Sciences, School of Dentistry The University of Michigan, Ann Arbor, Michigan 48109, USA; Department of Microbiology and Immunology, School of Medicine, The University of Michigan, Ann Arbor, Michigan 48109, USA. | en_US |
dc.identifier.pmid | 2556851 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27674/1/0000057.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0042-6822(89)90588-6 | en_US |
dc.identifier.source | Virology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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