Individualities in post-serotonin attenuation and Na+/K+ pump activity in vascular smooth muscle
dc.contributor.author | Bell, David R. | en_US |
dc.contributor.author | Babcock, Charlene M. | en_US |
dc.contributor.author | Bohr, David F. | en_US |
dc.date.accessioned | 2006-04-07T20:39:00Z | |
dc.date.available | 2006-04-07T20:39:00Z | |
dc.date.issued | 1989-11-21 | en_US |
dc.identifier.citation | Bell, David R., Babcock, Charlene M., Bohr, David F. (1989/11/21)."Individualities in post-serotonin attenuation and Na+/K+ pump activity in vascular smooth muscle." European Journal of Pharmacology 171(2-3): 189-199. <http://hdl.handle.net/2027.42/27684> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T1J-479DW3G-S9/2/b5ca959f235b1711bd115a02c23f6931 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27684 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2620702&dopt=citation | en_US |
dc.description.abstract | Prior treatment with serotonin (10-8-10-7 M for 6 min) attenuated responses of rabbit mesenteric arteries to norepinephrine (NE) by 18-62%, but was without effect on the responses of the rabbit aorta. K+ relaxation responses in the mesenteric arteries were enhanced by serotonin, but in the aortic strips no K+ relaxation occurred either before or after treatment with serotonin. Maximum relaxation to monensin was similar in the two tissues. Post-serotonin attenuation and K+ and monensin relaxation were blocked by ouabain, indicating that they depended on Na+/K+ pump stimulation. Intracellular Na+ contents (Nai) were determined in the vessels by the Li substitution method. Nai was greater, and was increased to a greater extent by serotonin and K+-free physiological salt solution in the mesenteric artery compared to the aorta, suggesting that the cell membrane of the mesenteric artery is leakier to Na+ than is that of the aorta. We conclude that the absence of post-serotonin attenuation in the aorta results from the failure of serotonin to increase Nai and thereby to stimulate the Na+/K+ pump in this tissue. This study demonstrates that important individualities in vascular smooth muscle reactivity even in the same animal may result from differences in membrane permeability to sodium. | en_US |
dc.format.extent | 776130 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Individualities in post-serotonin attenuation and Na+/K+ pump activity in vascular smooth muscle | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Physiology, University of Michigan, Ann Arbor, MI, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Physiology, University of Michigan, Ann Arbor, MI, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Physiology, University of Michigan, Ann Arbor, MI, U.S.A. | en_US |
dc.identifier.pmid | 2620702 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27684/1/0000067.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0014-2999(89)90107-6 | en_US |
dc.identifier.source | European Journal of Pharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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