Persistent cortisol non-suppression after clinical recovery predicts symptomatic relapse in unipolar depression
dc.contributor.author | Charles, Gerard A. | en_US |
dc.contributor.author | Schittecatte, Michel | en_US |
dc.contributor.author | Rush, A. John | en_US |
dc.contributor.author | Panzer, Michael | en_US |
dc.contributor.author | Wilmotte, Jean | en_US |
dc.date.accessioned | 2006-04-07T20:39:43Z | |
dc.date.available | 2006-04-07T20:39:43Z | |
dc.date.issued | 1989 | en_US |
dc.identifier.citation | Charles, Gerard A., Schittecatte, Michel, Rush, A. John, Panzer, Michael, Wilmotte, Jean (1989)."Persistent cortisol non-suppression after clinical recovery predicts symptomatic relapse in unipolar depression." Journal of Affective Disorders 17(3): 271-278. <http://hdl.handle.net/2027.42/27703> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T2X-4603GPD-58/2/dec347335f4c66f2d025837d977154d3 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27703 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2529296&dopt=citation | en_US |
dc.description.abstract | We assessed the length and the quality of remission of 13 unipolar endogenous depressed patients, DST non-suppressors before treatment, in a 2-year prospective study. During this period, we recorded stressful life events. Persistent dexamethasone non-suppression, after treatment and complete clinical recovery, correlated highly with early clinical relapse. All six non-normalizers but only one normalizer were rehospitalized within the following 2 years for a major depressive relapse. Persistent DST non-suppression was unrelated to any impact of drug discontinuation, the occurence of stresful life events or the length of illness-free intervals in the patient's prior course of illness. Persistent DST non-suppression appears to have significant prognostic value. | en_US |
dc.format.extent | 794011 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Persistent cortisol non-suppression after clinical recovery predicts symptomatic relapse in unipolar depression | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan Department of Psychiatry, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationother | Centre Hospitalier Vincent Van Gogh, Rue de l'Hôpital 55, B-6030 Charleroi, Belgium | en_US |
dc.contributor.affiliationother | Centre Hospitalier Vincent Van Gogh, Rue de l'Hôpital 55, B-6030 Charleroi, Belgium | en_US |
dc.contributor.affiliationother | University of Texas Health Science Center, Department of Psychiatry, Dallas, TX 75235, U.S.A. | en_US |
dc.contributor.affiliationother | Centre Hospitalier Vincent Van Gogh, Rue de l'Hôpital 55, B-6030 Charleroi, Belgium | en_US |
dc.identifier.pmid | 2529296 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27703/1/0000089.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0165-0327(89)90010-4 | en_US |
dc.identifier.source | Journal of Affective Disorders | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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