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Cholecystokinin receptor antagonism of stimulated pancreatic and gastric secretion
dc.contributor.authorMulholland, Michael W.en_US
dc.contributor.authorDebas, Haile T.en_US
dc.date.accessioned2006-04-07T20:39:54Z
dc.date.available2006-04-07T20:39:54Z
dc.date.issued1989-11en_US
dc.identifier.citationMulholland, Michael W., Debas, Haile T. (1989/11)."Cholecystokinin receptor antagonism of stimulated pancreatic and gastric secretion." Journal of Surgical Research 47(5): 460-464. <http://hdl.handle.net/2027.42/27708>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WM6-4BNF2MK-233/2/c7cb789bf36918148896dbe0a27b24f7en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/27708
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2478762&dopt=citationen_US
dc.description.abstractThe effects of cholecystokinin receptor antagonist, dipentyl-3,4-dichloroproglumide (DDP), on stimulated pancreatic and gastric secretion were studied in the rat. DDP dose-dependently inhibited cholecystokinin-stimulated amylase release from dispersed acinar cells. In vivo, DDP inhibited cholecystokinin octapeptide-stimulated amylase and protein secretion. DDP also inhibited pentagastrin-stimulated gastric acid secretion in vivo. Meal-stimulated acid output was decreased by 34% (DDP 400 [mu]g/kg/hr) but responsiveness to histamine or parachlorophenyl-[gamma]-aminobutyric acid was unchanged.en_US
dc.format.extent592080 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleCholecystokinin receptor antagonism of stimulated pancreatic and gastric secretionen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelSurgery and Anesthesiologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Surgery, University of Michigan, Ann Arbor, Michigan 49109, USAen_US
dc.contributor.affiliationotherDepartment of Surgery, University of California, San Francisco, California 94143, USAen_US
dc.identifier.pmid2478762en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/27708/1/0000094.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0022-4804(89)90102-9en_US
dc.identifier.sourceJournal of Surgical Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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