Mutagenicity of oxaspiro compounds with Salmonella
dc.contributor.author | Sinsheimer, Joseph E. | en_US |
dc.contributor.author | Chakraborty, Pulak K. | en_US |
dc.contributor.author | Messerly, E. A. | en_US |
dc.contributor.author | Gaddamidi, V. | en_US |
dc.date.accessioned | 2006-04-07T20:40:42Z | |
dc.date.available | 2006-04-07T20:40:42Z | |
dc.date.issued | 1989-10 | en_US |
dc.identifier.citation | Sinsheimer, J. E., Chakraborty, P. K., Messerly, E. A., Gaddamidi, V. (1989/10)."Mutagenicity of oxaspiro compounds with Salmonella." Mutation Research/Genetic Toxicology 224(2): 171-175. <http://hdl.handle.net/2027.42/27729> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B73FB-475BXYC-7/2/710ceb8a9823af3606c9494af40354d6 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27729 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2677708&dopt=citation | en_US |
dc.description.abstract | The spiro attachment of an epoxide group to a tetrahydropyran ring in the trichothecene mycotoxins has prompted this study of the mutagenicity and alkylation rates of the trichothecene, anguidine, and 5 related model oxaspiro compounds. While the model compounds were weak alkylating agents of 4-(4-nitrobenzyl)pyridine as a test nucleophile, anguidine lacks such activity. Also, while mutagenicity was not established for anguidine in Salmonella TA100, 3 of the oxaspiro compounds were weakly mutagenic and 2 compounds were toxic to the bacteria. The toxicity and mutagenicity of the model compounds are more related to their polarity than to their alkylation rates. | en_US |
dc.format.extent | 373354 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Mutagenicity of oxaspiro compounds with Salmonella | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, U.S.A. | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, U.S.A. | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, U.S.A. | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, U.S.A. | en_US |
dc.identifier.pmid | 2677708 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27729/1/0000121.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0165-1218(89)90153-5 | en_US |
dc.identifier.source | Mutation Research/Genetic Toxicology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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