View Item 

Show simple item record

HA-996 (1-hydroxy-3-aminopyrrolidone-2) selectively reduces (NMDA)-mediated brain damage
dc.contributor.authorMcDonald, John W.en_US
dc.contributor.authorUckele, John E.en_US
dc.contributor.authorSilverstein, Faye Sarahen_US
dc.contributor.authorJohnston, Michael V.en_US
dc.date.accessioned2006-04-07T20:41:40Z
dc.date.available2006-04-07T20:41:40Z
dc.date.issued1989-09-25en_US
dc.identifier.citationMcDonald, John W., Uckele, John, Silverstein, Faye S., Johnston, Michael V. (1989/09/25)."HA-996 (1-hydroxy-3-aminopyrrolidone-2) selectively reduces (NMDA)-mediated brain damage." Neuroscience Letters 104(1-2): 167-170. <http://hdl.handle.net/2027.42/27755>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T0G-485H7V1-186/2/164ecb1dcf21d12c28bcf3b2fd154fd1en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/27755
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2682393&dopt=citationen_US
dc.description.abstractThe neuroprotective effects of the strychnine-insensitive glycine receptor antagonist, HA-966, against (NMDA)- and quisqualate (QA)-mediated brain injury were determined in perinatal rats. Postnatal day (PND) 7 rats received intrastriatal injections of NMDA (25 nmol) or QA (100 nmol) and then were administered intraperitoneal (i.p.) injections of varying doses of HA-966 or vehicle 15 min later. Animals were sacrificed 5 days later and the degree of brain injury was calculated by comparison of the weights of injected and contralateral cerebral hemispheres. HA-966 selectively reduced the degree of NMDA-mediated brain injury in a dose-dependent manner. However, HA-966 did not attenuate QA-mediated brain injury.en_US
dc.format.extent269184 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleHA-996 (1-hydroxy-3-aminopyrrolidone-2) selectively reduces (NMDA)-mediated brain damageen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelPsychologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelSocial Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumNeuroscience and Medical Scientist Training Program, University of Michigan Medical School, Ann Arbor MI, U.S.A.en_US
dc.contributor.affiliationumDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor MI, U.S.A.; Department of Neurology, The Johns Hopkins University School of Medicine and the Kennedy Institute, Baltimore MD, U.S.A.en_US
dc.contributor.affiliationumDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor MI, U.S.A.; Department of Neurology, The Johns Hopkins University School of Medicine and the Kennedy Institute, Baltimore MD, U.S.A.en_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan Medical School, Ann Arbor MI, U.S.A.; Department of Pediatrics, The Johns Hopkins University School of Medicine and the Kennedy Institute, Baltimore MD, U.S.A.en_US
dc.identifier.pmid2682393en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/27755/1/0000148.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0304-3940(89)90349-2en_US
dc.identifier.sourceNeuroscience Lettersen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
0000148.pdf
Size:
262.8KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe its collections in a way that respects the people and communities who create, use, and are represented in them. We encourage you to Contact Us anonymously if you encounter harmful or problematic language in catalog records or finding aids. More information about our policies and practices is available at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.