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HA-996 (1-hydroxy-3-aminopyrrolidone-2) selectively reduces (NMDA)-mediated brain damage
dc.contributor.authorMcDonald, John W.en_US
dc.contributor.authorUckele, John E.en_US
dc.contributor.authorSilverstein, Faye Sarahen_US
dc.contributor.authorJohnston, Michael V.en_US
dc.date.accessioned2006-04-07T20:41:40Z
dc.date.available2006-04-07T20:41:40Z
dc.date.issued1989-09-25en_US
dc.identifier.citationMcDonald, John W., Uckele, John, Silverstein, Faye S., Johnston, Michael V. (1989/09/25)."HA-996 (1-hydroxy-3-aminopyrrolidone-2) selectively reduces (NMDA)-mediated brain damage." Neuroscience Letters 104(1-2): 167-170. <http://hdl.handle.net/2027.42/27755>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T0G-485H7V1-186/2/164ecb1dcf21d12c28bcf3b2fd154fd1en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/27755
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2682393&dopt=citationen_US
dc.description.abstractThe neuroprotective effects of the strychnine-insensitive glycine receptor antagonist, HA-966, against (NMDA)- and quisqualate (QA)-mediated brain injury were determined in perinatal rats. Postnatal day (PND) 7 rats received intrastriatal injections of NMDA (25 nmol) or QA (100 nmol) and then were administered intraperitoneal (i.p.) injections of varying doses of HA-966 or vehicle 15 min later. Animals were sacrificed 5 days later and the degree of brain injury was calculated by comparison of the weights of injected and contralateral cerebral hemispheres. HA-966 selectively reduced the degree of NMDA-mediated brain injury in a dose-dependent manner. However, HA-966 did not attenuate QA-mediated brain injury.en_US
dc.format.extent269184 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleHA-996 (1-hydroxy-3-aminopyrrolidone-2) selectively reduces (NMDA)-mediated brain damageen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelPsychologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelSocial Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumNeuroscience and Medical Scientist Training Program, University of Michigan Medical School, Ann Arbor MI, U.S.A.en_US
dc.contributor.affiliationumDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor MI, U.S.A.; Department of Neurology, The Johns Hopkins University School of Medicine and the Kennedy Institute, Baltimore MD, U.S.A.en_US
dc.contributor.affiliationumDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor MI, U.S.A.; Department of Neurology, The Johns Hopkins University School of Medicine and the Kennedy Institute, Baltimore MD, U.S.A.en_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan Medical School, Ann Arbor MI, U.S.A.; Department of Pediatrics, The Johns Hopkins University School of Medicine and the Kennedy Institute, Baltimore MD, U.S.A.en_US
dc.identifier.pmid2682393en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/27755/1/0000148.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0304-3940(89)90349-2en_US
dc.identifier.sourceNeuroscience Lettersen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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