Neurobehavioral effects of prenatal alcohol: Part II. Partial Least Squares analysis
dc.contributor.author | Sampson, Paul D. | en_US |
dc.contributor.author | Streissguth, Ann P. | en_US |
dc.contributor.author | Barr, Helen M. | en_US |
dc.contributor.author | Bookstein, Fred L. | en_US |
dc.date.accessioned | 2006-04-07T20:42:59Z | |
dc.date.available | 2006-04-07T20:42:59Z | |
dc.date.issued | 1989 | en_US |
dc.identifier.citation | Sampson, Paul D., Streissguth, Ann P., Barr, Helen M., Bookstein, Fred L. (1989)."Neurobehavioral effects of prenatal alcohol: Part II. Partial Least Squares analysis." Neurotoxicology and Teratology 11(5): 477-491. <http://hdl.handle.net/2027.42/27790> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T9X-47RWNT8-84/2/05ad49c4f97d8b1c015598459dd4d10d | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27790 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2593987&dopt=citation | en_US |
dc.description.abstract | This paper, the second in a series of three, introduces Partial Least Squares (PLS) methods for assessing the effects of moderate levels of prenatal alcohol exposure on performance and behavior in young school-age children. Studies of human behavioral teratology pose statistical problems for which standard multiple regression methods are inadequate. Prenatal alcohol exposure, the teratogenic "dose," can be assessed only indirectly through a variety of measures of alcohol consumption. Similarly, the behavioral outcomes we examine--IQ, achievement, classroom behavior, and vigilance--are each measured indirectly in terms of multiple items or indicators. We find that a single latent variable, estimated as a linear combination of the measures of alcohol consumption, provides an appropriate measure of "dose" for summarizing the relationships between alcohol exposure and each of the four blocks of outcome variables. A pattern of alcohol consumption emphasizing binge behavior (i.e., reporting average consumption of multiple drinks per drinking occasion, or at least five drinks on any single occasion) in the period prior to recognition of pregnancy is significantly correlated with latent variables computed from each of the four outcome blocks: IQ, academic achievement, classroom behavior and attention/vigilance. | en_US |
dc.format.extent | 1363594 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Neurobehavioral effects of prenatal alcohol: Part II. Partial Least Squares analysis | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Center for Human Growth and Development, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationother | Department of Statistics, University of Washington, Seattle, WA 98195, USA | en_US |
dc.contributor.affiliationother | Department of Psychiatry and Behavioral Sciences, the University of Washington, Seattle, WA 98195, USA; Alcoholism and Drug Abuse Institute, University of Washington, Seattle, WA 98195, USA; Child Development/Mental Retardation Center of the University of Washington, Seattle, WA 98195, USA | en_US |
dc.contributor.affiliationother | Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA | en_US |
dc.identifier.pmid | 2593987 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27790/1/0000188.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0892-0362(89)90025-1 | en_US |
dc.identifier.source | Neurotoxicology and Teratology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.