Stimulation of fibroblast proliferation by thrombospondin
dc.contributor.author | Phan, Sem H. | en_US |
dc.contributor.author | Dillon, Rene G. | en_US |
dc.contributor.author | McGarry, Bridget M. | en_US |
dc.contributor.author | Dixit, Vishva M. | en_US |
dc.date.accessioned | 2006-04-07T20:43:19Z | |
dc.date.available | 2006-04-07T20:43:19Z | |
dc.date.issued | 1989-08-30 | en_US |
dc.identifier.citation | Phan, Sem H., Dillon, Rene G., McGarry, Bridget M., Dixit, Vishva M. (1989/08/30)."Stimulation of fibroblast proliferation by thrombospondin." Biochemical and Biophysical Research Communications 163(1): 56-63. <http://hdl.handle.net/2027.42/27798> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-4F031HH-2CG/2/8cd343c7ca73cc40a0273e3b99ee2400 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27798 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2673242&dopt=citation | en_US |
dc.description.abstract | Thrombospondin purified from human platelets was examined for its ability to promote proliferation of human dermal fibroblasts. The results show that thrombospondin could stimulate the incorporation of [3H]thymidine by quiescent fibroblasts in a dose-dependent manner without stimulating protein or collagen synthesis. The effect was observed even in the total absence of serum, although the degree of stimulation was substantially lower than that in the presence of 0.4% fetal calf serum, but higher than that in the presence of 4% serum. The effect was specific and not due to contaminants as demonstrated by the ability of antibodies to thrombospondin to specifically inhibit this stimulation. Three monoclonal antibodies directed at different epitopes in the thrombospondin molecule were equally effective in inhibiting this effect. This stimulation of fibroblast proliferation by thrombospondin suggests a potential role for this matrix protein in the mesenchymal cell response in tissue injury and repair. | en_US |
dc.format.extent | 572992 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Stimulation of fibroblast proliferation by thrombospondin | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.identifier.pmid | 2673242 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27798/1/0000198.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-291X(89)92098-6 | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.