Potassium-induced release of endogenous glutamate and two as yet unidentified substances from the lateral line of Xenopus laevis
dc.contributor.author | Bledsoe, Sanford C., Jr. | en_US |
dc.contributor.author | McLaren, John D. | en_US |
dc.contributor.author | Meyer, Jeffrey R. | en_US |
dc.date.accessioned | 2006-04-07T20:45:21Z | |
dc.date.available | 2006-04-07T20:45:21Z | |
dc.date.issued | 1989-07-24 | en_US |
dc.identifier.citation | Bledsoe, Jr., Sanford C., McLaren, John D., Meyer, Jeffrey R. (1989/07/24)."Potassium-induced release of endogenous glutamate and two as yet unidentified substances from the lateral line of Xenopus laevis." Brain Research 493(1): 113-122. <http://hdl.handle.net/2027.42/27844> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYR-4847WWJ-1YD/2/925d9c8c3a017137949ca36bb8a5f685 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27844 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2570615&dopt=citation | en_US |
dc.description.abstract | The release of endogenous glutamate and other primary amines from the lateral line of Xenopus laevis was studied using an in vitro superfusion technique and high performance liquid chromatography. Potassium stimulation (50 mM KCl) applied to 60 or 120 lateral-line organs dissected from the skin and pooled in a perfusion chamber induced the release of glutamate and aspartate. The release of aspartate was smaller than that of glutamate and more variable. A variable release of two, as yet, unidentified substances was also detected. In low calcium (0.1 mM CaCl2), high magnesium (10 mM MgCl2) solution, 50 mM potassium failed to induce an increase in glutamate, aspartate and the two unknowns, suggesting they are released in a transmitter-like manner. The technique presents a new and simple method for studying transmitters in hair-cell systems. Although other interpretations are possible, the results are consistent with the hypothesis that glutamate is a hair-cell transmitter and suggest a potential role for other substances in the transduction process, perhaps as neuromodulators. | en_US |
dc.format.extent | 813818 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Potassium-induced release of endogenous glutamate and two as yet unidentified substances from the lateral line of Xenopus laevis | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan Medical School, Ann Arbor, MI 48109-0506, U.S.A. | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan Medical School, Ann Arbor, MI 48109-0506, U.S.A. | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan Medical School, Ann Arbor, MI 48109-0506, U.S.A. | en_US |
dc.identifier.pmid | 2570615 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27844/1/0000254.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-8993(89)91005-6 | en_US |
dc.identifier.source | Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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