Differential recognition of two cloned Brugia malayi antigens by antibody class
dc.contributor.author | Werner, Craig | en_US |
dc.contributor.author | Higashi, Gene I. | en_US |
dc.contributor.author | Yates, Jon A. | en_US |
dc.contributor.author | Rajan, Thiruchandurai V. | en_US |
dc.date.accessioned | 2006-04-07T20:46:16Z | |
dc.date.available | 2006-04-07T20:46:16Z | |
dc.date.issued | 1989-07 | en_US |
dc.identifier.citation | Werner, Craig, Higashi, Gene I., Yates, Jon A., Rajan, Thiruchandurai V. (1989/07)."Differential recognition of two cloned Brugia malayi antigens by antibody class." Molecular and Biochemical Parasitology 35(3): 209-218. <http://hdl.handle.net/2027.42/27866> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T29-476M0GP-86/2/fab4f5b5fffac9676f0508c38abd7a60 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27866 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2664506&dopt=citation | en_US |
dc.description.abstract | The humoral and cellular immune response to filarial parasites is complex. Numerous studies have shown that antibodies to a large number of protein and non-protein antigens may be produced over the course of infection and that immune recognition of any given antigen may vary by disease manifestation and by immunoglobulin class. We have used the techniques of molecular cloning to attempt to dissect this complex interaction, and describe here two clones, isolated from an expression library constructed from Brugia malayi genomic DNA, whose products are recognized by distinct immunoglobulin classes. A [lambda]gt11 fusion protein containing part of the B. malayi myosin tail region is recognized by antibodies of the IgG class from a high percentage of bancroftian filariasis patients. A fusion protein containing a collagen-like sequence is less frequently and weakly recognized under the same experimental conditions, but is almost universally recognized when the developing reagent is specific for IgE. We thus identify specific filarial proteins against which the infected human host responds preferentially with antibodies of a specific immunoglobulin class. | en_US |
dc.format.extent | 943050 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Differential recognition of two cloned Brugia malayi antigens by antibody class | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Biological Sciences, Oakland University, Rochester, MI, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, U.S.A.; Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, U.S.A. | en_US |
dc.identifier.pmid | 2664506 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27866/1/0000279.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0166-6851(89)90207-7 | en_US |
dc.identifier.source | Molecular and Biochemical Parasitology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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