The effects of kainic acid on the cochlear ganglion of the rat
dc.contributor.author | Juiz, Jose M. | en_US |
dc.contributor.author | Rueda, Joaquin | en_US |
dc.contributor.author | Merchan, Jaime A. | en_US |
dc.contributor.author | Sala, Maria Luisa | en_US |
dc.date.accessioned | 2006-04-07T20:46:57Z | |
dc.date.available | 2006-04-07T20:46:57Z | |
dc.date.issued | 1989-06-15 | en_US |
dc.identifier.citation | Juiz, Jose M., Rueda, Joaquin, Merchan, Jaime A., Sala, Maria Luisa (1989/06/15)."The effects of kainic acid on the cochlear ganglion of the rat." Hearing Research 40(1-2): 65-74. <http://hdl.handle.net/2027.42/27881> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T73-4864N1X-BF/2/13a1cc090252c163e4180fb581fe62a5 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27881 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2768084&dopt=citation | en_US |
dc.description.abstract | The effects of locally applied kainic acid on cells and fibers in the rat cochlea were examined in a quantitative and ultrastructural study. Doses of 5 nM per [mu]1 of artificial perilymph destroyed part of the spiral ganglion type I cell population, with no ototoxic effects on cochlear hair cells or supporting cells. Type II cells also appeared unaffected. A quantitative evaluation of the cell loss with the 5 nM dosage showed that 34% of spiral ganglion neurons were lost 10 days after treatment. Doses of 20 nM per [mu]l and 40 nM per [mu]1 did not result in increasing neuronal loss.This differential toxicity could reflect the presence of a sub-population of spiral ganglion cells with an increased number of KA receptors. | en_US |
dc.format.extent | 1708766 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The effects of kainic acid on the cochlear ganglion of the rat | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, The University of Michigan, Ann Arbor, Michigan, U.S.A.; Department of Histology, University of Alicante, Alicante, Spain. | en_US |
dc.contributor.affiliationother | Department of Histology, University of Alicante, Alicante, Spain | en_US |
dc.contributor.affiliationother | Department of Histology, University of Alicante, Alicante, Spain | en_US |
dc.contributor.affiliationother | Department of Histology, University of Alicante, Alicante, Spain | en_US |
dc.identifier.pmid | 2768084 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27881/1/0000295.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0378-5955(89)90100-7 | en_US |
dc.identifier.source | Hearing Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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