Cyclosporine a inhibits TNF production without decreasing TNF mRNA levels
dc.contributor.author | Remick, Daniel G. | en_US |
dc.contributor.author | Nguyen, Dung T. | en_US |
dc.contributor.author | Eskandari, Mark K. | en_US |
dc.contributor.author | Strieter, Robert M. | en_US |
dc.contributor.author | Kunkel, Steven L. | en_US |
dc.date.accessioned | 2006-04-07T20:47:08Z | |
dc.date.available | 2006-04-07T20:47:08Z | |
dc.date.issued | 1989-06-15 | en_US |
dc.identifier.citation | Remick, Daniel G., Nguyen, Dung T., Eskandari, Mark K., Strieter, Robert M., Kunkel, Steven L. (1989/06/15)."Cyclosporine a inhibits TNF production without decreasing TNF mRNA levels." Biochemical and Biophysical Research Communications 161(2): 551-555. <http://hdl.handle.net/2027.42/27885> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-4DXRXVK-5C/2/663b49f68996c1eed5a181b028e161a8 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27885 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2735909&dopt=citation | en_US |
dc.description.abstract | The role of cytokines in health and disease has received increasing attention and numberous investigations have explored the regulation of cytokine gene expression. Tumor necrosis factor-[alpha] (TNF) has received particular attention because of its central role in septic shock and more recent work has shown its participation in transplant immunology. We explored the mechanism of cyclosporine A (CsA) modulation of complete Freunds adjuvant macrophage (CFA-MO) TNF gene expression. From 0.001 to 1 ug/ml, CsA dose-dependently inhibited lipopolysaccharide (LPS) induced secreted bioactivity; at doses above 10[mu]g/ml CSA was directly toxic to CFA-MO. However, there was no suppression of TNF mRNA levels, and CsA also did not inhibit the accumulation of cell-associated TNF. Thus, CsA modulates TNF gene expression in a previously undescribed manner. | en_US |
dc.format.extent | 806682 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Cyclosporine a inhibits TNF production without decreasing TNF mRNA levels | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, Box 0602 Room M5214 1301 Catherine Road The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Pathology, Box 0602 Room M5214 1301 Catherine Road The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Pathology, Box 0602 Room M5214 1301 Catherine Road The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Box 0602 Room M5214 1301 Catherine Road The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Pathology, Box 0602 Room M5214 1301 Catherine Road The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 2735909 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27885/1/0000299.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-291X(89)92634-X | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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