Effects of thromboxane synthetase inhibition on patency and anastomotic hyperplasia of vascular grafts
dc.contributor.author | Graham, Linda M. | en_US |
dc.contributor.author | Brothers, Thomas E. | en_US |
dc.contributor.author | Darvishian, David | en_US |
dc.contributor.author | Harrell, Karyn A. | en_US |
dc.contributor.author | Vincent, Christopher K. | en_US |
dc.contributor.author | Burkel, William E. | en_US |
dc.contributor.author | Stanley, James C. | en_US |
dc.date.accessioned | 2006-04-07T20:48:50Z | |
dc.date.available | 2006-04-07T20:48:50Z | |
dc.date.issued | 1989-06 | en_US |
dc.identifier.citation | Graham, Linda M., Brothers, Thomas E., Darvishian, David, Harrell, Karyn A., Vincent, Christopher K., Burkel, William E., Stanley, James C. (1989/06)."Effects of thromboxane synthetase inhibition on patency and anastomotic hyperplasia of vascular grafts." Journal of Surgical Research 46(6): 611-615. <http://hdl.handle.net/2027.42/27929> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WM6-4BNG2CS-G1/2/8e0c64903322c3357a01b8202776577d | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27929 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2659898&dopt=citation | en_US |
dc.description.abstract | The efficacy of a thromboxane synthetase inhibitor (U-63,557A, Upjohn) in promoting early patency and inhibiting anastomotic intimal hyperplasia in ePTFE grafts was compared to that of acetylsalicylic acid (ASA) in a canine model. Animals were started on ASA 5 gr po qd (Group I, n = 12) or U-63,557A 10 mg/kg po bid (Group II, n = 12) 1 day before placement of bilateral 5-mm-i.d., 13- to 16.5-cm-long ePTFE aortoiliac grafts and continued on the medication for the 16-week study. Six dogs in each group received autologous endothelial cell-seeded grafts, while the other six received unseeded grafts. Patency was determined weekly by assessment of femoral pulses. At the conclusion of the study anastomotic intimal hyperplasia was measured on serial sections through the distal anastomosis using a computer-linked digitizer. In Group I the patencies of seeded and unseeded grafts were not significantly different, being 100 and 83%, respectively. Furthermore, luminal narrowing due to intimal hyperplasia was not significantly different being 9.1 +/- 7.6% (x +/- SD) in seeded grafts and 8.8 +/- 8.1% in unseeded grafts. On the other hand, in Group II the seeded grafts had significantly improved patency when compared to the unseeded grafts (83% vs 33%, P P P P < 0.01). | en_US |
dc.format.extent | 685516 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Effects of thromboxane synthetase inhibition on patency and anastomotic hyperplasia of vascular grafts | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Surgery and Anesthesiology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Surgery and Anatomy and Cell Biology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA; Department of Surgery, Case Western Reserve University, Cleveland, Ohio 44106, USA. | en_US |
dc.contributor.affiliationum | Department of Surgery, Case Western Reserve University, Cleveland, Ohio 44106, USA; Departments of Surgery and Anatomy and Cell Biology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA. | en_US |
dc.contributor.affiliationum | Department of Surgery, Case Western Reserve University, Cleveland, Ohio 44106, USA; Departments of Surgery and Anatomy and Cell Biology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA. | en_US |
dc.contributor.affiliationum | Department of Surgery, Case Western Reserve University, Cleveland, Ohio 44106, USA; Departments of Surgery and Anatomy and Cell Biology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA. | en_US |
dc.contributor.affiliationum | Department of Surgery, Case Western Reserve University, Cleveland, Ohio 44106, USA; Departments of Surgery and Anatomy and Cell Biology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA. | en_US |
dc.contributor.affiliationum | Department of Surgery, Case Western Reserve University, Cleveland, Ohio 44106, USA; Departments of Surgery and Anatomy and Cell Biology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA. | en_US |
dc.contributor.affiliationum | Department of Surgery, Case Western Reserve University, Cleveland, Ohio 44106, USA; Departments of Surgery and Anatomy and Cell Biology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA. | en_US |
dc.identifier.pmid | 2659898 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27929/1/0000353.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0022-4804(89)90030-9 | en_US |
dc.identifier.source | Journal of Surgical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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