The beta form is the dominant interleukin released by murine peritoneal macrophages
dc.contributor.author | Chensue, Stephen W. | en_US |
dc.contributor.author | Shmyr-Forsch, C. | en_US |
dc.contributor.author | Otterness, Ivan G. | en_US |
dc.contributor.author | Kunkel, Steven L. | en_US |
dc.date.accessioned | 2006-04-07T20:50:18Z | |
dc.date.available | 2006-04-07T20:50:18Z | |
dc.date.issued | 1989-04-14 | en_US |
dc.identifier.citation | Chensue, S. W., Shmyr-Forsch, C., Otterness, I. G., Kunkel, S. L. (1989/04/14)."The beta form is the dominant interleukin released by murine peritoneal macrophages." Biochemical and Biophysical Research Communications 160(1): 404-408. <http://hdl.handle.net/2027.42/27968> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-4DN93SM-HD/2/2f1f00409ded73cccd0e274c89b989c2 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27968 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2653321&dopt=citation | en_US |
dc.description.abstract | Using highly specific polyclonal antisera raised against recombinant murine IL-1 [alpha] and [beta], we performed solid-phase immunoabsorption studies on supernates of resident and adjuvant-elicited CBA/J mouse peritoneal macrophages. Antibody specificity was established by reciprocal absorption studies and Western blot analysis. Supernates obtained from macrophages cultured for 18 hr in the presence of 1[mu]g/ml lipopolysaccharide (LPS) were subjected to immunoabsorption. Approximately 78-90% of the released bioactive material was IL-1 and about 80% of this could be attributed to IL-1 [beta]. Analogous to that reported for human monocytes, these data suggest that IL-1 [beta] is the predominant released form of IL-1. | en_US |
dc.format.extent | 333017 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The beta form is the dominant interleukin released by murine peritoneal macrophages | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Pfizer Central Research, Groton, Connecticut 06340, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA. | en_US |
dc.contributor.affiliationum | Pfizer Central Research, Groton, Connecticut 06340, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA. | en_US |
dc.contributor.affiliationum | Pfizer Central Research, Groton, Connecticut 06340, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA. | en_US |
dc.contributor.affiliationum | Pfizer Central Research, Groton, Connecticut 06340, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA. | en_US |
dc.identifier.pmid | 2653321 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27968/1/0000399.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-291X(89)91670-7 | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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