16, 16 Dimethyl prostaglandin E2 decreases the formation of collagen in fibrotic rat liver slices
dc.contributor.author | Peters, Ken M. | en_US |
dc.contributor.author | Snyder, K. F. | en_US |
dc.contributor.author | Rush, B. D. | en_US |
dc.contributor.author | Ruwart, M. J. | en_US |
dc.contributor.author | Henley, Keith S. | en_US |
dc.date.accessioned | 2006-04-07T20:51:28Z | |
dc.date.available | 2006-04-07T20:51:28Z | |
dc.date.issued | 1989-04 | en_US |
dc.identifier.citation | Peters, K. M., Snyder, K. F., Rush, B. D., Ruwart, M. J., Henley, K. S. (1989/04)."16, 16 Dimethyl prostaglandin E2 decreases the formation of collagen in fibrotic rat liver slices." Prostaglandins 37(4): 445-456. <http://hdl.handle.net/2027.42/27997> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T3H-47MJMF9-XF/2/f9f793e5b33219562ba986bf232b9736 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27997 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2762555&dopt=citation | en_US |
dc.description.abstract | The effect of 16, 16 dimethyl prostaglandin E2 (DMPG) on fibrogenesis was studied in slices from normal and fibrotic rat liver. Rats received a cirrhogenic diet for seven months; supplemented controls received a diet with the deficient nutrients restored. Slices from fibrotic livers incorporated more 14C-proline and produced more 14C-hydroxyproline in TCA precipitable proteins than slices from control livers. DMPG (10-10M) decreased the incorporation of labeled proline and the synthesis of labeled hydroxyproline in slices from fibrotic livers to the same extent, suggesting that DMPG did not affect the hydroxylation of proline per se. The magnitude of the DMPG induced decrease in labeled proline incorporation correlated with the hydroxyproline content in the liver (i.e. with increasing fibrosis there was a greater effect of DMPG; while in control rat liver slices, DMPG had no effect). DMPG did not change the size of the proline pool, its specific activity, or the activity of proline oxidase. We conclude that under these conditions of enhanced fibrogenesis, DMPG decreases the formation of collagen in vitro, possibly by lowering the incorporation of proline into collagen precursors. This may explain, at least in part, the inhibition of fibrogenesis by DMPG in vivo. | en_US |
dc.format.extent | 476352 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | 16, 16 Dimethyl prostaglandin E2 decreases the formation of collagen in fibrotic rat liver slices | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Dept. of Internal Medicine (Gastroenterology), The University of Michigan, Ann Arbor, MI, 48109, USA | en_US |
dc.contributor.affiliationum | Dept. of Internal Medicine (Gastroenterology), The University of Michigan, Ann Arbor, MI, 48109, USA | en_US |
dc.contributor.affiliationother | Diabetes and Gastrointestinal Diseases Research, The Upjohn Company, Kalamazoo, MI 49001, USA | en_US |
dc.contributor.affiliationother | Diabetes and Gastrointestinal Diseases Research, The Upjohn Company, Kalamazoo, MI 49001, USA | en_US |
dc.contributor.affiliationother | Diabetes and Gastrointestinal Diseases Research, The Upjohn Company, Kalamazoo, MI 49001, USA | en_US |
dc.identifier.pmid | 2762555 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27997/1/0000432.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0090-6980(89)90094-4 | en_US |
dc.identifier.source | Prostaglandins | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.