Interactions of small polypeptides with dimyristoylphosphatidylcholine monolayers: effect of size and hydrophobicity
dc.contributor.author | Williams, N. Adeyinka | en_US |
dc.contributor.author | Weiner, Norman D. | en_US |
dc.date.accessioned | 2006-04-07T20:52:05Z | |
dc.date.available | 2006-04-07T20:52:05Z | |
dc.date.issued | 1989-03-15 | en_US |
dc.identifier.citation | Williams, N. A., Weiner, N. D. (1989/03/15)."Interactions of small polypeptides with dimyristoylphosphatidylcholine monolayers: effect of size and hydrophobicity." International Journal of Pharmaceutics 50(3): 261-266. <http://hdl.handle.net/2027.42/28014> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T7W-475TBSY-X/2/9ac3a6ad1e7fb2e8c133831860d04b5e | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28014 | |
dc.description.abstract | The effects of size and hydrophobicity of small (molecular weights below 2,000) polypeptides on their predominantly hydrophobic interactions with a neutral phospholipid monolayer were studied. The changes in surface pressure were determined when various concentrations of Gly, Gly-Gly-Gly, -Ala, -Ala--Ala--Ala, -Ala-Gly-Gly-Gly-Gly, -Phe--Leu--Glu--Glu--Leu, adrenocorticotropic hormone fragments 1-10 (ACTH-(1-10)), porcine [beta]-lipotropin, [alpha]-endorphin and human fibrinopeptide A were injected under dimyristoylphosphatidylcholine (DMPC) monolayers at an initial surface pressure of 10 dyne/cm. In all cases, when peptides with the same number of residues are compared, the concentration needed to increase the surface pressure of the film by 1 dyne/cm was inversely related to its hydrophobicity. A reasonably good correlation was found to exist between the calculated free energy of transfer of a polypeptide from ethanol to water (a measure of its hydrophobicity) and its ability to increase the surface pressure of the DMPC film (a measure of the extent of its interaction with the neutral lipid monolayer). | en_US |
dc.format.extent | 608732 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Interactions of small polypeptides with dimyristoylphosphatidylcholine monolayers: effect of size and hydrophobicity | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28014/1/0000450.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0378-5173(89)90129-4 | en_US |
dc.identifier.source | International Journal of Pharmaceutics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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