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Absence of detectable xanthine oxidase in human myocardium

dc.contributor.authorGrum, Cyril M.en_US
dc.contributor.authorGallagher, Kim P.en_US
dc.contributor.authorKirsh, Marvin M.en_US
dc.contributor.authorShlafer, Marshalen_US
dc.date.accessioned2006-04-07T20:52:49Z
dc.date.available2006-04-07T20:52:49Z
dc.date.issued1989-03en_US
dc.identifier.citationGrum, Cyril M., Gallagher, Kim P., Kirsh, Marvin M., Shlafer, Marshal (1989/03)."Absence of detectable xanthine oxidase in human myocardium." Journal of Molecular and Cellular Cardiology 21(3): 263-267. <http://hdl.handle.net/2027.42/28034>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WK6-4C547MM-J7/2/0c2ee2cddd9ebb5dd5e0fcf15dd519a0en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/28034
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2746653&dopt=citationen_US
dc.description.abstractThe enzyme xanthine oxidase has been implicated as a generator of toxic oxygen metabolites that contribute to ischemic injury. Because substantial species variability has been demonstrated and because there are minimal human data available, the relevance of xanthine oxidase to human heart damage has been in doubt. We report the absence of xanthine oxidase activity in nine human heart biopsy specimens obtained during cardiac surgery, and in two larger samples obtained during heart transplantation. A sensitive radiochemical assay was used to assess enzyme activity. Our findings imply that oxygen free radicals generated by xanthine oxidase are not relevent in terms of human myocardial injury.en_US
dc.format.extent413631 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleAbsence of detectable xanthine oxidase in human myocardiumen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine (Pulmonary and Critical Care Division), The University of Michigan Medical School, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Physiology, The University of Michigan Medical School, Ann Arbor, MI, USA; Department of Surgery (Section of Thoracic Surgery), The University of Michigan Medical School, Ann Arbor, MI, USA.en_US
dc.contributor.affiliationumDepartment of Surgery (Section of Thoracic Surgery), The University of Michigan Medical School, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Pharmacology, The University of Michigan Medical School, Ann Arbor, MI, USA; Department of Surgery (Section of Thoracic Surgery), The University of Michigan Medical School, Ann Arbor, MI, USA.en_US
dc.identifier.pmid2746653en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/28034/1/0000473.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0022-2828(89)90741-4en_US
dc.identifier.sourceJournal of Molecular and Cellular Cardiologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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