Dopamine D-1 and D-2 receptor antagonists potentiate analgesic and motor effects of morphine
dc.contributor.author | Kiritsy-Roy, Judith A. | en_US |
dc.contributor.author | Standish, Scott M. | en_US |
dc.contributor.author | Cass Terry, L. | en_US |
dc.date.accessioned | 2006-04-07T20:53:07Z | |
dc.date.available | 2006-04-07T20:53:07Z | |
dc.date.issued | 1989-03 | en_US |
dc.identifier.citation | Kiritsy-Roy, Judith A., Standish, Scott M., Cass Terry, L. (1989/03)."Dopamine D-1 and D-2 receptor antagonists potentiate analgesic and motor effects of morphine." Pharmacology Biochemistry and Behavior 32(3): 717-721. <http://hdl.handle.net/2027.42/28042> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0N-479KKH1-XH/2/32f3b44f327191027f4b6037673f9294 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28042 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2662224&dopt=citation | en_US |
dc.description.abstract | To examine the role of dopamine receptor subtypes mediating analgesic and motor responses to opioids, rats were pretreated with either saline or a selective D-1 or D-2 dopamine receptor antagonist 10 min prior to morphine (12 mg/kg IP). Analgesic response latency was determined using the hot plate test (52.5[deg]C and 55[deg]C), and catalepsy was assessed using the abnormal posture test. Morphine increased analgesic response latency to 44.5 +/- 7.9% of the maximum possible response, but had no cataleptic effect in the abnormal posture test. Pretreatment with either the D-1 antagonist, SCH 23390 (50-100 [mu]g/kg), or the D-2 antagonist, eticlopride (20-150 [mu]g/kg), potently enhanced morphine analgesia as measured on the 52.5[deg]C hot plate. Peak analgesic responses to morphine increased to 100 +/- 0% and 91.9 +/- 7.5% of maximum with the highest doses of SCH 23390 and eticlopride, respectively. These treatments also produced catalepsy. Increasing the hot plate temperature to 55[deg]C reduced response latency in groups treated with either dopamine receptor antagonist plus morphine. This indicates that the animals were capable of responding at a shorter latency and demonstrates that motor impairment cannot account for potentiation of morphine analgesia by D-1 and D-2 antagonists at 52.5[deg]C. These results show that the relationship between dopamine and opioids with respect to analgesic and motor systems involves both dopamine receptor subtypes. | en_US |
dc.format.extent | 544628 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Dopamine D-1 and D-2 receptor antagonists potentiate analgesic and motor effects of morphine | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Physiology, University of Michigan, Ann Arbor, MI 48109, USA. | en_US |
dc.contributor.affiliationum | Department of Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Institute of Gerontology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Neuroendocrine Research Laboratory, Veterans Administration Medical Center, Ann Arbor, MI 48105, USA; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA. | en_US |
dc.contributor.affiliationother | Department of Neuroendocrine Research Laboratory, Veterans Administration Medical Center, Ann Arbor, MI 48105, USA | en_US |
dc.identifier.pmid | 2662224 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28042/1/0000481.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0091-3057(89)90023-3 | en_US |
dc.identifier.source | Pharmacology Biochemistry and Behavior | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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