Cocaine: evidence for supraspinal, dopamine-mediated, non-opiate analgesia
dc.contributor.author | Lin, Yu | en_US |
dc.contributor.author | Morrow, Thomas J. | en_US |
dc.contributor.author | Kiritsy-Roy, Judith A. | en_US |
dc.contributor.author | Cass Terry, L. | en_US |
dc.contributor.author | Casey, Kenneth L. | en_US |
dc.date.accessioned | 2006-04-07T20:53:40Z | |
dc.date.available | 2006-04-07T20:53:40Z | |
dc.date.issued | 1989-02-13 | en_US |
dc.identifier.citation | Lin, Yu, Morrow, Thomas J., Kiritsy-Roy, Judith A., Cass Terry, L., Casey, Kenneth L. (1989/02/13)."Cocaine: evidence for supraspinal, dopamine-mediated, non-opiate analgesia." Brain Research 479(2): 306-312. <http://hdl.handle.net/2027.42/28057> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYR-485PBKP-18B/2/5a50cc4ed7538033d26cd546a8b4a1a1 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28057 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2647210&dopt=citation | en_US |
dc.description.abstract | Cocaine (25 mg/kg i.p.) produces analgesia in the rat within 5 min and for a duration of 90 min as determined by the formalin test or for 30 min as determined by the hot plate test. Cocaine analgesia is unaffected by doses of naloxone that are sufficient to attenuate morphine analgesia in both tests. Chlorpromazine (3 mg/kg i.p.), SCH 23390 (100 [mu]g/kg i.p.; a D1 dopamine receptor antagonist), and eticlopride (75 [mu]g/kg i.p.; a D2 dopamine receptor antagonist) each attenuate cocaine analgesia in both tests at doses that alone do not affect performance in either test. Measurements of blood pressure and heart rate indicate that cocaine analgesia is not due to the activation of baroreceptor reflex afferents. We conclude that cocaine is a supraspinally acting, dopamine-mediated, non-opiate analgesic in the rat. | en_US |
dc.format.extent | 722715 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Cocaine: evidence for supraspinal, dopamine-mediated, non-opiate analgesia | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Neurology Research Laboratories, Veterans Administration Medical Center, Ann Arbor, MI 48105, U.S.A.; Department of Physiology, University of Michigan, USA. | en_US |
dc.contributor.affiliationum | Department of Physiology, University of Michigan, USA; Neurology Research Laboratories, Veterans Administration Medical Center, Ann Arbor, MI 48105, U.S.A.; Department of Neurology, University of Michigan, USA. | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, USA; Department of Physiology, University of Michigan, USA; Neurology Research Laboratories, Veterans Administration Medical Center, Ann Arbor, MI 48105, U.S.A. | en_US |
dc.contributor.affiliationother | Neurology Research Laboratories, Veterans Administration Medical Center, Ann Arbor, MI 48105, U.S.A. | en_US |
dc.contributor.affiliationother | Neurology Research Laboratories, Veterans Administration Medical Center, Ann Arbor, MI 48105, U.S.A. | en_US |
dc.identifier.pmid | 2647210 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28057/1/0000496.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-8993(89)91633-8 | en_US |
dc.identifier.source | Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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