The competitive N-methyl-D-aspartate (NMDA) antagonist CGS 19755 attenuates the rate-decreasing effects of NMDA in rhesus monkeys without producing ketamine-like discriminative stimulus effects
dc.contributor.author | France, Charles P. | en_US |
dc.contributor.author | Woods, James H. | en_US |
dc.contributor.author | Ornstein, Paul | en_US |
dc.date.accessioned | 2006-04-07T20:54:57Z | |
dc.date.available | 2006-04-07T20:54:57Z | |
dc.date.issued | 1989-01-10 | en_US |
dc.identifier.citation | France, Charles P., Woods, James H., Ornstein, Paul (1989/01/10)."The competitive N-methyl-D-aspartate (NMDA) antagonist CGS 19755 attenuates the rate-decreasing effects of NMDA in rhesus monkeys without producing ketamine-like discriminative stimulus effects." European Journal of Pharmacology 159(2): 133-139. <http://hdl.handle.net/2027.42/28089> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T1J-4746947-KY/2/8a8ca34adcadefa83add7bd0a02a6b9c | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28089 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2651134&dopt=citation | en_US |
dc.description.abstract | The purported competitive excitatory amino acid antagonist CGS 19755 was compared to the non-competitive antagonists ketamine and MK-801 in three rhesus monkeys discriminating between 1.78 mg/kg of ketamine and saline while responding under a fixed-ratio 100 schedule of food presentation. MK-801 substituted completely for the ketamine discriminative stimulus and was 32 times more potent than ketamine as a discriminative stimulus. CGS 19755 was studies using sinlge and cumulative dosing procedures up to a dose of 10.0 mg/kg; for all conditions, CGS 19755 produced responding exclusively on the saline lever and had only modest rate-decreasing effects. N-Methyl-D-aspartate administered alone also did not produce ketamine-appropriate responding but did decrease response rates in a dose-related manner. N-Methyl-D-aspartate eliminated responding in all monkeys at doses of 5.6-10.0 mg/kg. MK-801 and ketamine antagonized the rate-decreasing effects of N-methyl-D-asparate, however, ketamine was most effective as an antagonist at doses that decreased response effects of N-methyl-D-asparate, however, ketamine was most the rate-decreasing effects of N-methyl-D-aspartate and shifted the N-methyl-D-aspartate dose-effect curve more than 5-fold to the right. The magnitude of antagonism of N-methyl-D-aspartate appeared to be somewhat greater with CGS 19755 than with MK-801 or ketamine. Thus, a competitive (CGS 19755) and some non-competitive (MK-801 and ketamine) excitatory amino acid antagonists can attenuate the rate-decreasing effects of N-methyl-D-aspartate. Surprisingly, the results suggest that antagonism of N-methyl-D-aspartate is not sufficient to produce ketamine-like discriminative stimulus effects under these conditions in rhesus monkeys. | en_US |
dc.format.extent | 499005 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The competitive N-methyl-D-aspartate (NMDA) antagonist CGS 19755 attenuates the rate-decreasing effects of NMDA in rhesus monkeys without producing ketamine-like discriminative stimulus effects | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychology and Pharmacology, University of Michigan, Ann Arbor, MI 48109-0626, USA | en_US |
dc.contributor.affiliationum | Department of Psychology and Pharmacology, University of Michigan, Ann Arbor, MI 48109-0626, USA | en_US |
dc.contributor.affiliationother | Lilly Research Laboratories, Indianapolis, IN 46825, U.S.A. | en_US |
dc.identifier.pmid | 2651134 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28089/1/0000536.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0014-2999(89)90697-3 | en_US |
dc.identifier.source | European Journal of Pharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.